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The Role of Lipid Transfer Proteins as Food and Pollen Allergens Outside the Mediterranean Area
- Source :
- Current Allergy and Asthma Reports, Current allergy and asthma reports, 21(2):7
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Purpose of Review To provide an overview of the prevalence and clinical manifestation of non-specific lipid transfer proteins (LTP)-mediated allergies outside the Mediterranean area and to address potential reasons for the different geographical significance of LTP-driven allergies. Recent Findings LTPs are major allergens in the Mediterranean area, which frequently can elicit severe reactions. Pru p 3 the LTP from peach is reported as genuine allergen and is considered a prototypic marker for LTP-mediated allergies. However, both food and pollen LTP allergies exist outside the Mediterranean area, but with lower clinical significance, different immunogenicity, and less clarified role. Summary Evidence has been reported that in areas with high exposure to pollen, in particular to mugwort, pollen-derived LTPs can act as a primary sensitizer to trigger secondary food allergies. Co-sensitization to unrelated allergens might be causative for less severe reactions in response to LTPs. However, the reason for the geographical different sensitization patterns to LTPs remains unclear.
- Subjects :
- 0301 basic medicine
Pulmonary and Respiratory Medicine
Allergy
Pru p 3
Immunology
Cross Reactions
Biology
Mugwort
medicine.disease_cause
03 medical and health sciences
LTP syndrome
0302 clinical medicine
Allergen
Non-specific lipid transfer protein
Pollen
Prevalence
medicine
Humans
Immunology and Allergy
Clinical significance
Sensitization
Plant Proteins
musculoskeletal, neural, and ocular physiology
Immunogenicity
Lebensmittelallergie
LTP
Pollenallergie
Allergens
Antigens, Plant
Immunoglobulin E
medicine.disease
030104 developmental biology
medicine.anatomical_structure
Artemisia
nervous system
030228 respiratory system
Allergens (RK Bush and S Vieths, Section Editors)
Carrier Proteins
Plant lipid transfer proteins
Food Hypersensitivity
Subjects
Details
- ISSN :
- 15346315 and 15297322
- Volume :
- 21
- Database :
- OpenAIRE
- Journal :
- Current Allergy and Asthma Reports
- Accession number :
- edsair.doi.dedup.....e2d13194a035ee6a7d6051c5bfdbe868