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Multi-wavelength photo-acoustic microscopy in the frequency domain for simultaneous excitation and detection of dyes
- Source :
- Biomedical optics express, Biomedical optics express, Optical Society of America-OSA Publishing, 2019, 10 (2), pp.932. ⟨10.1364/boe.10.000932⟩
- Publication Year :
- 2019
- Publisher :
- Optical Society of America, 2019.
-
Abstract
- International audience; An optical-resolution photoacoustic microscope with modulated CW laser diodes allowing multi-channel imaging is presented that can be used for both imaging biological tissues and for targeted photo-dynamic therapy (PDT) varying the optical power and exposure time. The effects of this therapy are immediately monitored in order to optimize the time of irradiation. After the description of the experimental setup, in vitro and in vivo applications are presented on a synthetic sample and on the mouse ear using hemoglobin as endogenous and methylene blue as exogenous dye for imaging and PDT, respectively.
- Subjects :
- Materials science
Microscope
Optical power
01 natural sciences
Article
law.invention
010309 optics
03 medical and health sciences
chemistry.chemical_compound
law
0103 physical sciences
Microscopy
Medical imaging
Irradiation
030304 developmental biology
Diode
[PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics]
0303 health sciences
business.industry
Atomic and Molecular Physics, and Optics
eye diseases
chemistry
Frequency domain
Optoelectronics
business
Methylene blue
Biotechnology
Subjects
Details
- Language :
- English
- ISSN :
- 21567085
- Database :
- OpenAIRE
- Journal :
- Biomedical optics express, Biomedical optics express, Optical Society of America-OSA Publishing, 2019, 10 (2), pp.932. ⟨10.1364/boe.10.000932⟩
- Accession number :
- edsair.doi.dedup.....e2bfd3b5d999c29c74e5f27f13485744