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Blood lead, nutrient intake, and renal function among type 2 diabetic patients
- Source :
- Environmental Science and Pollution Research. 28:49063-49073
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Lead (Pb) exposure has been reported to have nephrotoxicity. However, such an effect has not been well investigated in type 2 diabetes (T2D) patients, especially when taking into account the nutrition status of the patients. Therefore, we explore the association between blood lead levels (BLLs), dietary intake of nutrients, and impaired renal function among patients with T2D. We measured BLLs and biochemical parameters of renal injury in 780 patients. Dietary nutrients intake was assessed by a food frequency questionnaire in 420 of 780 participants. We found high BLLs were significantly associated with certain parameters of renal injury, and dietary intake of specific nutrients (mainly micronutrients) was associated with reduced BLLs at high percentile distribution of concentration. BLLs were also found to have moderation effects on the association between specific dietary nutrients and specific renal function parameters.
- Subjects :
- Health, Toxicology and Mutagenesis
Physiology
Renal function
Nutrient intake
Type 2 diabetes
010501 environmental sciences
Kidney
01 natural sciences
Nephrotoxicity
Eating
Nutrient
Renal injury
Humans
Environmental Chemistry
Medicine
Lead (electronics)
0105 earth and related environmental sciences
business.industry
General Medicine
medicine.disease
Micronutrient
Pollution
Diabetes Mellitus, Type 2
Lead
Energy Intake
business
Subjects
Details
- ISSN :
- 16147499 and 09441344
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Environmental Science and Pollution Research
- Accession number :
- edsair.doi.dedup.....e2bcd84843c4c2dd12c6ebc0d27af876