Brazilian guidelines on hematopoietic stem cell transplantation in acute myeloid leukemia

Introduction/ Objectives Acute myeloid leukemia (AML) accounts for 90% of all cases of acute leukemia in adults. In Brazil the mortality from myeloid leukemias was 1.74/100.000 men and 1.37/100.000 women. Our aim is to review and update guidelines of the Brazilian Society of Bone Marrow Transplantation on indications of hematopoietic stem cell transplantation (HSCT) for the treatment AML Conclusions 1) Allo-HSCT is recommended for high-risk AML (IA); 2) Allo-HSCT is recommended for AML of intermediate risk (IA); 3) Allo-HSCT is recommended for AML relapsed / refractory (C4); 4) Auto-HSCT is recommended for AML after 1 consolidation (C4); 5) Auto-HSCT is recommended for AML in CR1 (higher than QT in the Brazilian experience) (C4); 6) Auto-HSCT is accepted for AML M3 in second molecular complete remission (2B); 7) Peripheral Blood instead of Bone Marrow HSC for advanced disease (2A); 8) Recommended conditioning protocols: Bu-Cy / Bu-Mel, Bu-Flu, TBI-Cy. In umbilical cord HSCT consider ATG based protocols (2A); 9) Allogeneic HSCT for the treatment of AML can be used in patients between 60 and 80 years with good performance status and absence of significant comorbidities (C4). This article is protected by copyright. All rights reserved.