Back to Search
Start Over
Leptin concentration indexed to fat mass is increased in untreated anorexia nervosa (AN) patients
- Source :
- Clinical endocrinology. 71(1)
- Publication Year :
- 2008
-
Abstract
- Summary Context Data regarding serum adipocytokine and ghrelin concentrations in different stages of anorexia nervosa (AN) is conflicting. Objective Our aim is to determine serum concentrations of adiponectin (ApN), leptin and ghrelin in different stages of AN and to evaluate their relationships with study parameters. Design setting and participants Study group was composed of four subgroups: Group 1: patients with a recent diagnosis of AN (n = 19); group 2: weight recovered (10% increase in body weight compared with baseline) subgroup of group 1 during follow-up (n = 10); group 3: recovered patients with a previous history of AN but normal menstrual cycles and body weight currently (n = 10); group 4: control group (n = 10). Venous blood was obtained for measurements of biochemical/hormonal parameters, ApN, leptin and ghrelin. Body composition was determined by bioimpedance analysis. Main outcome measures Changes in adipocytokine and ghrelin concentrations and relationships with anthropometric/biochemical parameters. Results Leptin : fat mass (kg) ratio was significantly higher in group 1 patients compared with group 4 (4·3 ± 4·6 vs. 1·1 ± 0·5 µg/l kg, P
- Subjects :
- Adult
Leptin
Male
medicine.medical_specialty
Anorexia Nervosa
Endocrinology, Diabetes and Metabolism
Adipokine
Anorexia
Body Mass Index
Young Adult
Endocrinology
Internal medicine
medicine
Humans
Adiponectin
business.industry
digestive, oral, and skin physiology
Body Weight
Venous blood
Ghrelin
Adipose Tissue
Anorectic
Female
medicine.symptom
business
Body mass index
hormones, hormone substitutes, and hormone antagonists
Subjects
Details
- ISSN :
- 13652265
- Volume :
- 71
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical endocrinology
- Accession number :
- edsair.doi.dedup.....e2b9a94992f2462b9addb411a0573c42