Back to Search
Start Over
Treatment of patients with Mayer-Rokitansky- Küster-Hauser syndrome in a tertiary hospital
- Source :
- Hong Kong medical journal = Xianggang yi xue za zhi. 26(5)
- Publication Year :
- 2020
-
Abstract
- Introduction Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is an uncommon congenital malformation characterised by agenesis or hypoplasia of the vagina and uterus. Here, we describe the treatment of patients with MRKH syndrome in a tertiary hospital. Methods This retrospective study included patients with MRKH syndrome attending the Paediatric and Adolescent Gynaecology Clinic in a tertiary hospital. Their clinical manifestations, examinations, and methods for neovagina creation were recorded. Among patients who underwent vaginal dilation (VD), therapy duration, vaginal width and length at baseline and after VD, complications, and sexual activity and dyspareunia outcomes were evaluated. Results Forty nine patients with MRKH syndrome were identified. Their mean age at presentation was 17.9 years; 69.4% and 24.5% of patients presented for primary amenorrhoea treatment and vaginoplasty, respectively. Forty eight patients had normal renal imaging findings and 46 XX karyotypes. Seventeen (34.7%) patients underwent VD as first-line therapy; three did not complete the therapy. Two had surgical vaginoplasty, whereas five achieved adequate vaginal length by sexual intercourse alone; 25 had not yet requested VD. The mean duration of VD was 16±10.2 (range, 4-35) weeks. The widths and lengths of the vagina at baseline and after VD were 1.1±0.28 cm and 1.3±0.7 cm, and 3.1±0.5 cm and 6.9±0.9 cm, respectively. The overall success rate of VD was 92.3%. Vaginal spotting was the most common complication (21%); only one patient reported dyspareunia. Conclusions Mayer-Rokitansky-Kuster-Hauser syndrome is an uncommon condition that requires multidisciplinary specialist care. Vaginal dilation is an effective first-line approach for neovagina creation.
- Subjects :
- medicine.medical_specialty
46, XX Disorders of Sex Development
Adolescent
Congenital Abnormalities
Tertiary Care Centers
medicine
Humans
Mayer-Rokitansky-Kuster-Hauser Syndrome
Forty Nine
Mullerian Ducts
Retrospective Studies
business.industry
Retrospective cohort study
Plastic Surgery Procedures
medicine.disease
Dilatation
Hypoplasia
Surgery
medicine.anatomical_structure
Treatment Outcome
Agenesis
Vagina
Vaginoplasty
Female
Complication
business
Subjects
Details
- ISSN :
- 10242708
- Volume :
- 26
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Hong Kong medical journal = Xianggang yi xue za zhi
- Accession number :
- edsair.doi.dedup.....e2b939b13102cacee184a4e93e48ee79