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Role of single prolonged stress in acquisition of alcohol conditioned place preference in rats
- Source :
- Life Sciences. 151:259-263
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- Aims Previous studies showed that exposure to certain types of stressors enhance the rewarding effects of many drugs of abuse, including alcohol; however, no systematic study has investigated the role of single prolonged stress (SPS) in acquisition of alcohol conditioned place preference (CPP). The purpose of this study was to examine whether SPS would facilitate the acquisition of alcohol CPP in rats. Main methods Male Sprague-Dawley rats were randomly assigned to either SPS exposure condition or no exposure condition. Freezing behavior and Elevated plus maze (EPM) were employed to evaluate PTSD-like symptoms induced by SPS. Further, using unbiased procedure, CPP conditioning was conducted with alcohol (2 g/kg). Key findings SPS significantly enhanced freezing behavior of rats, decreased percentages (%) of both time spent and number of entry into the open arms, and facilitated the acquisition of alcohol CPP without inhibiting rats' activity. Significance Our findings suggest that SPS plays an important role in alcohol dependence, and CPP paradigm with SPS may be useful for exploring the rewarding mechanism of alcohol with regard to the interaction between alcohol and post-traumatic stress disorder (PTSD).
- Subjects :
- Male
Restraint, Physical
medicine.medical_specialty
Elevated plus maze
education
Alcohol
Motor Activity
Ether
General Biochemistry, Genetics and Molecular Biology
Stress Disorders, Post-Traumatic
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Reward
Stress, Physiological
Internal medicine
Conditioning, Psychological
medicine
Animals
General Pharmacology, Toxicology and Pharmaceutics
Maze Learning
Swimming
Electroshock
Ethanol
business.industry
Stressor
Alcohol dependence
Immobility Response, Tonic
General Medicine
Conditioned place preference
Rats
030227 psychiatry
Freezing behavior
Endocrinology
chemistry
Conditioning
business
psychological phenomena and processes
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 00243205
- Volume :
- 151
- Database :
- OpenAIRE
- Journal :
- Life Sciences
- Accession number :
- edsair.doi.dedup.....e2a80263ec489349ff4bc23cf3406723