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Cancer Incidence and Mortality Rates in Multiple Sclerosis
- Source :
- Neurology. 96:e501-e512
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- ObjectiveTo determine whether cancer risk differs in people with and without multiple sclerosis (MS), we compared incidence rates and cancer-specific mortality rates in MS and matched cohorts using population-based data sources.MethodsWe conducted a retrospective matched cohort study using population-based administrative data from Manitoba and Ontario, Canada. We applied a validated case definition to identify MS cases, then selected 5 controls without MS matched on birth year, sex, and region. We linked these cohorts to cancer registries, and estimated incidence of breast, colorectal, and 13 other cancers. For breast and colorectal cancers, we constructed Cox models adjusting for age at the index date, area-level socioeconomic status, region, birth cohort year, and comorbidity. We pooled findings across provinces using meta-analysis.ResultsWe included 53,983 MS cases and 269,915 controls. Multivariable analyses showed no difference in breast cancer risk (pooled hazard ratio [HR] 0.92 [95% confidence interval (CI) 0.78–1.09]) or colorectal cancer risk (pooled HR 0.83 [95% CI 0.64–1.07]) between the cohorts. Mortality rates for breast and colorectal did not differ between cohorts. Bladder cancer incidence and mortality rates were higher among the MS cohort. Although the incidence of prostate, uterine, and CNS cancers differed between the MS and matched cohorts, mortality rates did not.ConclusionThe incidence of breast and colorectal cancers does not differ between persons with and without MS; however, the incidence of bladder cancer is increased. Reported differences in the incidence of some cancers in the MS population may reflect ascertainment differences rather than true differences.
- Subjects :
- Adult
Male
medicine.medical_specialty
Multiple Sclerosis
Adolescent
Cohort Studies
Young Adult
03 medical and health sciences
0302 clinical medicine
Breast cancer
Neoplasms
Internal medicine
medicine
Humans
Prospective Studies
Registries
Mortality
Prospective cohort study
Aged
Retrospective Studies
Ontario
business.industry
Incidence
Incidence (epidemiology)
Mortality rate
Cancer
Manitoba
Retrospective cohort study
Middle Aged
medicine.disease
Research Design
030220 oncology & carcinogenesis
Cohort
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Cohort study
Subjects
Details
- ISSN :
- 1526632X and 00283878
- Volume :
- 96
- Database :
- OpenAIRE
- Journal :
- Neurology
- Accession number :
- edsair.doi.dedup.....e2a44be1eb7e538950e1de26fa311135