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Grafted Neural Stem Cells Shield the Host Environment from Oxidative Stress
- Source :
- Annals of the New York Academy of Sciences. 1049:185-188
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- Here, we present our preliminary data showing that neural stem cells (NSCs) can prevent the degeneration of striatal neurons when transplanted into the CNS prior to intoxication with 3-nitropropionic acid (3-NP). In the adult CNS, the number of NSCs, a major source of neural cell populations and plasticity-modulating factors, is relatively low if compared to that of the developing brain. This, together with the adult growth-inhibitory environment, limits its regenerative capacity. Our recent observation has shown that grafted NSCs may rescue/protect neurons in the chronically impaired mesostriatal system. On the basis of this study and because we were also intrigued by our recent observations regarding the rescue/protective role of NSCs in vitro, we decided to test the hypothesis that grafted NSCs can also be deposited preventively in the CNS (and perhaps join the pool of endogenous NSCs of the intact host brain) for later buffering and maintenance of homeostasis when the host is exposed to oxidative stress.
- Subjects :
- Neurons
Stem Cells
General Neuroscience
Regeneration (biology)
Endogeny
Biology
medicine.disease_cause
Neuroprotection
General Biochemistry, Genetics and Molecular Biology
Neural stem cell
Oxidative Stress
nervous system
History and Philosophy of Science
Nerve Degeneration
medicine
Animals
Brain Tissue Transplantation
biological phenomena, cell phenomena, and immunity
Neuroscience
Neural cell
reproductive and urinary physiology
Homeostasis
Oxidative stress
Stem Cell Transplantation
Subjects
Details
- ISSN :
- 00778923
- Volume :
- 1049
- Database :
- OpenAIRE
- Journal :
- Annals of the New York Academy of Sciences
- Accession number :
- edsair.doi.dedup.....e29431414345dc5a76cb8ce400d43375