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Short-Term Effects of Growth Hormone on Lipolysis, Glucose and Amino Acid Metabolism Assessed in Serum and Microdialysate of Healthy Young Men
- Source :
- Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 128(12)
- Publication Year :
- 2019
-
Abstract
- Objective We investigated direct effects of a therapeutic growth hormone dose on lipolysis, glucose and amino acid metabolism. Methods This crossover microdialysis trial involved six healthy male volunteers receiving single subcutaneous injections of both growth hormone (0.035 mg/kg) and placebo (0.9% sodium chloride). The investigation comprised three test days with standard diet. The first day served for adaptation, the second and third one for determining study data during 9 night hours with or without growth hormone. Abdominal subcutaneous microdialysate and blood were continuously collected and forwarded to a separate room next door where hourly taken samples were centrifuged and frozen until analysed. Results Growth hormone achieved the peak serum level after 3 h followed by a plateau-like course for the next 6 h. Glycerol in microdialysate started to rise 2 h following growth hormone injection achieving significance compared to placebo after 9 h (P Summary and Conclusion As the result of a high single subcutaneous dose of GH, persistent lipolysis can be shown in continuously collected microdialysate and blood, but no indication for gluconeogenesis or protein anabolism.
- Subjects :
- 0301 basic medicine
Adult
Blood Glucose
Glycerol
Male
medicine.medical_specialty
Microdialysis
Endocrinology, Diabetes and Metabolism
Sodium
Lipolysis
chemistry.chemical_element
030209 endocrinology & metabolism
Growth hormone
Placebo
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Endocrinology
Pharmacokinetics
Internal medicine
Internal Medicine
medicine
Humans
Amino Acids
Cross-Over Studies
business.industry
General Medicine
030104 developmental biology
Glucose
chemistry
Gluconeogenesis
Growth Hormone
business
Subjects
Details
- ISSN :
- 14393646
- Volume :
- 128
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Experimental and clinical endocrinologydiabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
- Accession number :
- edsair.doi.dedup.....e280817517c17c04f1a1fffb8a06da64