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Fragility fracture identifies patients at imminent risk for subsequent fracture: real-world retrospective database study in Ontario, Canada
- Source :
- BMC Musculoskeletal Disorders, Vol 22, Iss 1, Pp 1-10 (2021), BMC Musculoskeletal Disorders
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Background The secondary fracture prevention gap in the osteoporosis field has been previously described as a ‘crisis’. Closing this gap is increasingly important in the context of accumulating evidence showing that an incident fragility fracture is associated with an increased risk of subsequent fracture within 1–2 years, known as imminent fracture risk. The objective of this study was to use health services data to characterize the time between index fragility fractures occurring at different osteoporotic sites and subsequent fractures. Methods This retrospective observational study used de-identified health services data from the publicly funded healthcare system in Ontario, the largest province of Canada. Patients aged > 65 with an index fragility fracture occurring between 2011 and 2015 were identified from the ICES Data Repository using International Classification of Diseases (ICD)-10 codes. We examined median time to subsequent fragility fractures for osteoporotic fracture sites until the end of follow-up (2017). BMD assessment and use of osteoporosis therapies following index fracture were also characterized. Results Among 115,776 patients with an index fragility fracture, 17.8% incurred a second fragility fracture. Median time between index and second fracture occurring at any site was 555 days (interquartile range: 236–955). For each index fracture site examined, median time from index to second fracture was 3 years post index fracture. Conclusions This cohort of Canadian patients aged > 65 years who experienced a fragility fracture at any site are at imminent risk of experiencing subsequent fracture within the next 2 years and should be proactively assessed and treated.
- Subjects :
- medicine.medical_specialty
lcsh:Diseases of the musculoskeletal system
Osteoporosis
Secondary fracture prevention
030209 endocrinology & metabolism
Context (language use)
03 medical and health sciences
0302 clinical medicine
Fragility
Rheumatology
Interquartile range
Epidemiology
Secondary Prevention
Humans
Medicine
Orthopedics and Sports Medicine
030212 general & internal medicine
Aged
Retrospective Studies
Imminent fracture risk
Ontario
Bone Density Conservation Agents
business.industry
Retrospective cohort study
Subsequent fracture
Fragility fracture
medicine.disease
Real-world data
Emergency medicine
Cohort
Fracture (geology)
Post fracture care
lcsh:RC925-935
business
Osteoporotic Fractures
Research Article
Subjects
Details
- ISSN :
- 14712474
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- BMC Musculoskeletal Disorders
- Accession number :
- edsair.doi.dedup.....e271c33f049e9cbf24ff6e132d880eac