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Potential association of specific Candida parapsilosis genotypes, bloodstream infections and colonization of health workers' hands
- Source :
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 20(11)
- Publication Year :
- 2014
-
Abstract
- Fungal nosocomial infections continue to be a serious problem among hospitalized patients, decreasing quality of life and adding millions of euros to healthcare costs. The aim of this study was to describe the pattern of fungi associated with the hands of healthcare workers and to genotype Candida parapsilosis isolates in order to understand whether their high clinical prevalence stems from endemic nosocomial genotypes or from the real emergence of epidemiologically-unrelated strains. Approximately 39% (50/129) of healthcare workers were positive for yeasts and among 77 different fungal isolates recovered, C. parapsilosis was the most frequent (44/77; 57%). Twenty-seven diverse genotypes were obtained by microsatellite analysis of 42 selected blood and hand isolates. Most of the isolates from hands showed a new, unrelated, genotype, whereas a particular group of closely related genotypes prevailed in blood samples. Some of the latter genotypes were also found on the hands of healthcare workers, indicating a persistence of these clones within our hospital. C. parapsilosis genotypes from the hands were much more heterogeneous than clinical ones, thus reflecting a high genetic diversity among isolates, which is notably unusual and unexpected for this species.
- Subjects :
- Microbiology (medical)
Candida parapsilosis
microsatellite genotyping
Settore MED/17 - Malattie Infettive
Genotype
Sepsi
Hospitalized patients
Health Personnel
Fungal pathogen
Nosocomial fungal infection
Infectious Disease
Biology
Persistence (computer science)
Microbiology
Candida species
Candidaemia
fungal pathogens
healthcare workers
nosocomial fungal infections
Retrospective Studie
Sepsis
Disease Transmission, Infectious
Humans
Colonization
DNA, Fungal
Mycological Typing Techniques
Candida
Retrospective Studies
Genetic diversity
Cross Infection
Molecular Epidemiology
Medicine (all)
Fungal pathogens
Healthcare workers
Microsatellite genotyping
Nosocomial fungal infections
Hand
Molecular Typing
Infectious Diseases
General Medicine
biology.organism_classification
Disease Transmission, Infectiou
Microsatellite Analysis
Candida specie
Healthcare worker
Candida parapsilosi
Mycological Typing Technique
Human
Subjects
Details
- ISSN :
- 14690691
- Volume :
- 20
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
- Accession number :
- edsair.doi.dedup.....e26e2a361dca4f86635255a5d0a0118c