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Dopamine DRD2/ANKK1 Taq1A and DAT1 VNTR polymorphisms are associated with a cognitive flexibility profile in pathological gamblers
- Source :
- Journal of Psychopharmacology. 28:1170-1177
- Publication Year :
- 2014
- Publisher :
- SAGE Publications, 2014.
-
Abstract
- Like drug addiction, pathological gambling (PG) has been associated with impairments in executive functions and alterations in dopaminergic functioning; however, the role of dopamine (DA) in the executive profile of PG remains unclear. The aim of this study was to identify whether the DRD2/ANKK1 Taq1A-rs1800497 and the DAT1-40 bp VNTR polymorphisms are associated with cognitive flexibility (measured by Wisconsin Card Sorting Test (WCST) and Trail Making Test (TMT)) and inhibition response (measured by Stroop Color and Word Test (SCWT)), in a clinical sample of 69 PG patients. Our results showed an association between DA functioning and cognitive flexibility performance. The Taq1A A1+ (A1A2/A1A1) genotype was associated with poorer TMT performance ( p < 0.05), while DAT1 9-repeat homozygotes displayed better WCST performance ( p < 0.05) than either 10-repeat homozygotes or heterozygotes. We did not find any association between the DRD2 or DAT1 polymorphisms and the inhibition response. These results suggested that pathological gamblers with genetic predispositions toward lower availability of DA and D2 receptor density are at a higher risk of cognitive flexibility difficulties. Future studies should aim to shed more light on the genetic mechanisms underlying the executive profile in PG.
- Subjects :
- Adult
Male
Oncology
medicine.medical_specialty
Adolescent
Genotype
Trail Making Test
Dopamine transport
Minisatellite Repeats
Neuropsychological Tests
Protein Serine-Threonine Kinases
Young Adult
Cognition
Wisconsin Card Sorting Test
Internal medicine
medicine
Humans
Pharmacology (medical)
Psychiatry
Aged
Pharmacology
Dopamine Plasma Membrane Transport Proteins
ANKK1
Polymorphism, Genetic
Receptors, Dopamine D2
Dopaminergic
Cognitive flexibility
Middle Aged
Executive functions
Psychiatry and Mental health
Gambling
Psychology
Stroop effect
Subjects
Details
- ISSN :
- 14617285 and 02698811
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Psychopharmacology
- Accession number :
- edsair.doi.dedup.....e26616371cbf729c105e3d38efe95a51