Back to Search
Start Over
Inhibitor of DNA binding in heart development and cardiovascular diseases
- Source :
- Cell Communication and Signaling : CCS, Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-11 (2019)
- Publication Year :
- 2019
-
Abstract
- Id proteins, inhibitors of DNA binding, are transcription regulators containing a highly conserved helix-loop-helix domain. During multiple stages of normal cardiogenesis, Id proteins play major roles in early development and participate in the differentiation and proliferation of cardiac progenitor cells and mature cardiomyocytes. The fact that a depletion of Ids can cause a variety of defects in cardiac structure and conduction function is further evidence of their involvement in heart development. Multiple signalling pathways and growth factors are involved in the regulation of Ids in a cell- and tissue- specific manner to affect heart development. Recent studies have demonstrated that Ids are related to multiple aspects of cardiovascular diseases, including congenital structural, coronary heart disease, and arrhythmia. Although a growing body of research has elucidated the important role of Ids, no comprehensive review has previously compiled these scattered findings. Here, we introduce and summarize the roles of Id proteins in heart development, with the hope that this overview of key findings might shed light on the molecular basis of consequential cardiovascular diseases. Furthermore, we described the future prospective researches needed to enable advancement in the maintainance of the proliferative capacity of cardiomyocytes. Additionally, research focusing on increasing embryonic stem cell culture adaptability will help to improve the future therapeutic application of cardiac regeneration.
- Subjects :
- Id
Inhibitor of DNA binding
Cell
lcsh:Medicine
Review
Biology
Bioinformatics
Biochemistry
Heart development
chemistry.chemical_compound
Transcription (biology)
medicine
Animals
Humans
Myocytes, Cardiac
lcsh:QH573-671
Receptor
Molecular Biology
Cardiac conduction system
lcsh:Cytology
Proliferative capacity
lcsh:R
Heart
Cell Biology
Embryonic stem cell
medicine.anatomical_structure
chemistry
Cardiovascular Diseases
Inhibitor of Differentiation Proteins
Electrical conduction system of the heart
DNA
Subjects
Details
- ISSN :
- 1478811X
- Volume :
- 17
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Cell communication and signaling : CCS
- Accession number :
- edsair.doi.dedup.....e247be4cbe7386c45dc8d16ac5c1346d