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DZIP3 is a key factor to stratify IDH1 wild-type lower-grade gliomas
- Source :
- Aging (Albany NY)
- Publication Year :
- 2020
- Publisher :
- Impact Journals, 2020.
-
Abstract
- Background: Malignant glioma is the most common form of primary malignant brain cancer. Heterogeneity is the hallmark of glioma. DAZ-interacting zinc finger 3 (DZIP3), acts as an RNA-binding RING-type ubiquitin ligase; however, its function in glioma is yet unclear. Results: The DZIP3 expression was related to the World Health Organization (WHO) grade and isocitrate dehydrogenase 1(IDH1) status, as well as the clinical outcome. Malignant cases exhibit lower DZIP3 expression. DZIP3 was an independent predictive factor of good prognosis in all grade and lower grade gliomas (p < 0.0001). Gene enrichment analysis and immunohistochemistry indicated that DZIP3 affected the biological behavior of glioma through the angiogenesis pathway. Moreover, based on DZIP3 expression, IDH1 wild-type lower-grade gliomas could be divided into two groups with different survival time. Conclusion: In conclusion, the loss of DZIP3 may be involved in the mechanism of angiogenesis in the invasive biological process of glioma. These findings laid an understanding of DZIP3-specific clinical features in glioma. Methods: A total of 325 glioma patients from the Chinese Glioma Genome Atlas (CGGA) RNA-seq cohort comprised the training cohort, while 265 patients from the GSE 16011 array cohort formed the validation cohort. The mRNA expression of DZIP3 and clinical characteristics was assessed. DZIP3 protein expression and microvessel density (MVD) were evaluated by immunohistochemistry (IHC).
- Subjects :
- Oncology
Aging
medicine.medical_specialty
IDH1
Angiogenesis
Ubiquitin-Protein Ligases
Oligodendroglioma
Angiogenesis Pathway
Astrocytoma
Internal medicine
Glioma
medicine
Humans
RNA, Messenger
RNA-Seq
survival time
IDH1 wild-type
biology
Neovascularization, Pathologic
business.industry
Brain Neoplasms
RNA-Binding Proteins
Cell Biology
medicine.disease
Prognosis
Immunohistochemistry
Isocitrate Dehydrogenase
Ubiquitin ligase
Survival Rate
Isocitrate dehydrogenase
Cohort
biology.protein
DZIP3
Neoplasm Grading
business
Glioblastoma
Research Paper
Subjects
Details
- Language :
- English
- ISSN :
- 19454589
- Volume :
- 12
- Issue :
- 24
- Database :
- OpenAIRE
- Journal :
- Aging (Albany NY)
- Accession number :
- edsair.doi.dedup.....e2433d4a09c5146efa4e9ec9336487a5