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Age-dependent systemic DNA damage in early Type 2 Diabetes mellitus
- Publication Year :
- 2017
-
Abstract
- Oxidative stress, capable of eliciting damage to various biomolecules including DNA, is a recognized component of diabetes mellitus and its complications. Metabolic syndrome (MetS) is associated with the development of type 2 diabetes mellitus (T2DM), as well as other unfavorable outcomes. The aim of this study was to elucidate the role of oxidative stress in the development of T2DM, by investigating association of oxidative DNA damage with metabolic parameters in subjects with MetS and early T2DM.Selected anthropometric and biochemical parameters of MetS, inflammation and oxidative DNA damage: body mass index (BMI), fatty liver index (FLI), waist circumference (WC), total cholesterol, HDL and LDL-cholesterol, GGT, uric acid, total leukocyte/neutrophil count, and urinary 8-oxo-deoxyguanosine (u-8-oxodG) were assessed in male subjects with MetS and both younger (≤55 years) and older (>55 years) subjects with T2DM of short duration without complications.BMI, FLI, WC, total and LDL-cholesterol and uric acid were higher, while the u-8-oxodG was lower in MetS group, when compared to older T2DM subjects. None of these parameters were different neither between MetS and younger T2DM, nor between two sub-groups of subjects with T2DM. Values of CRP, HDL-cholesterol, triglycerides, GGT, leukocytes and neutrophils were not different between all examined groups of subjects. Age-dependent increase in u-8-oxodG suggests that aging process, rather than metabolic disturbances or diabetes per se plays a pivotal role in development of oxidative DNA-damage in T2DM. Oxidative DNA damage cannot serve as an universal early marker of T2DM.
- Subjects :
- Adult
Male
0301 basic medicine
Aging
medicine.medical_specialty
endocrine system diseases
DNA damage
Blood Pressure
Biology
medicine.disease_cause
General Biochemistry, Genetics and Molecular Biology
Body Mass Index
03 medical and health sciences
chemistry.chemical_compound
Risk Factors
Internal medicine
Diabetes mellitus
medicine
Humans
Aged
Metabolic Syndrome
Cholesterol, HDL
Fatty liver
metabolic syndrome
type 2 diabetes mellitus
urinary 8-OHdG
Type 2 Diabetes Mellitus
nutritional and metabolic diseases
Middle Aged
medicine.disease
Fatty Liver
Oxidative Stress
C-Reactive Protein
Cholesterol
030104 developmental biology
Endocrinology
Diabetes Mellitus, Type 2
chemistry
Uric acid
Female
Metabolic syndrome
Body mass index
Oxidative stress
DNA Damage
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e23d79d3939c03529ca04bdc541fba5a