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Vitamin D metabolism in preterm infants: effect of a calcium load
- Source :
- Biology of the neonate. 53(6)
- Publication Year :
- 1988
-
Abstract
- Decrease in serum calcium level leading to hypocalcemia during the first week of life is a frequent finding in premature neonates. Eight premature neonates presenting with such an episode of hypocalcemia in the course of their first 4 days of life were studied. They were fed with a phosphate-enriched human milk and given vitamin D3 (2,100 IU/day per os). We have evaluated the effect of a 24-hour pharmacologic calcium infusion on the circulating levels of calcium, inorganic phosphate, magnesium, 25-hydroxycalciferol (25-OHD), 1α,25-dihydroxycalciferol [1,25(OH)2D] and immunoreactive parathyroid hormone (iPTH). After the infusion, circulating iPTH and Pi levels dropped significantly (p < 0.025 and p < 0.005 respectively) whereas serum Ca and 25-OHD (p < 0.005) increased. Mg and 1,25(OH)2D serum levels remained unchanged. Our data show that an increased calcium supply sustained for 24 h induces an appropriate response in iPTH secretion. Effects on circulating levels of 1,25(OH)2D were variable and probably reflected individual differences in half life of 1,25(OH)2D or in set points in the feedback mechanisms involved in the control of 1,25(OH)2D synthesis.
- Subjects :
- Male
medicine.medical_specialty
chemistry.chemical_element
Infant, Premature, Diseases
Calcium
Gluconates
Phosphates
Calcitriol
Internal medicine
Vitamin D and neurology
medicine
Humans
Magnesium
Calcifediol
1α 25 dihydroxyvitamin d
Vitamin D metabolism
Hypocalcemia
Chemistry
Infant, Newborn
Vitamina d
Metabolism
Calcium Gluconate
Endocrinology
Parathyroid Hormone
Pediatrics, Perinatology and Child Health
Female
Serum Calcium Level
Developmental Biology
Subjects
Details
- ISSN :
- 00063126
- Volume :
- 53
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Biology of the neonate
- Accession number :
- edsair.doi.dedup.....e2275afd0985af8bfad8037afc0697b9