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Characterization and biodistribution of bevacizumab TPGS-based nanomicelles: Preliminary studies
- Publication Year :
- 2016
- Publisher :
- Elsevier Science, 2016.
-
Abstract
- Bevacizumab is an FDA approved monoclonal antibody (anti VEGF) indicated in many cancers, mostly metastatic ones. D-α-tocopheryl polyethylene glycol succinate (TPGS) is the water-soluble form of vitamin E which usually forms micelles. This work aims to report preliminary results of the biodistribution of a TPGS based nano-micelle delivery system for bevacizumab in a gastric cancer xenograft model. Evaluation of the biodistribution of micelles/bevacizumab-99mTc was performed in Balb/c nude mice carrying MKN45 cell line xenograft. The nano-radiopharmaceutical (3.7 MBq/0.2 mL) was administered intraocularly and biodistribution was assesed 1 h post administration. The activity in each organ and blood was determined by a gamma counter. Mean size was 10 ± 1 nm for pure TPGS and 11 ± 1 nm for bevacizumab-TPGS respectively. Biodistribution showed that the highest uptake was found in both lungs and liver. Kidneys had also an important uptake. The tumor accumulated moderate to low radiolabeled nanomicelles, nevertheless tumor/blood ratio was very high. These preliminary results may help as a start point to continue evaluating the potential of radiolabeled bevacizumab-TPGS based nanomicelles to be used as a theranostic agent. Fil: Tesan, Fiorella Carla. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Cerqueira Coutinho, Cristal. Universidade Federal do Rio de Janeiro; Brasil Fil: Salgueiro, María Jimena. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Albernaz, Marta de Souza. Universidade Federal do Rio de Janeiro; Brasil Fil: Pinto, Suyenne Rocha. Universidade Estadual da Zona Oeste; Brasil Fil: Reis, Sara Rhaissa Rezende Dos. Universidade Estadual da Zona Oeste; Brasil Fil: Bernardes, Emerson Soares. Instituto de Pesquisas Energéticas e Nucleares; Brasil Fil: Chiapetta, Diego. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Zubillaga, Marcela Beatriz. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina Fil: Santos Oliveira, Ralph. Universidade Estadual da Zona Oeste; Brasil
- Subjects :
- Biodistribution
Materials science
CIENCIAS MÉDICAS Y DE LA SALUD
Bevacizumab
medicine.drug_class
medicine.medical_treatment
Pharmaceutical Science
Ciencias de la Salud
02 engineering and technology
Polyethylene glycol
Pharmacology
Monoclonal antibody
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Mkn45
medicine
Nanomicelles
Gamma counter
Vitamin E
Cancer
Tpgs
021001 nanoscience & nanotechnology
medicine.disease
Otras Ciencias de la Salud
chemistry
030220 oncology & carcinogenesis
Delivery system
0210 nano-technology
medicine.drug
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....e217e808f13a713d43a0618247f43e1e