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Relationship of Sarcopenia with Microcirculation Measured by Skin Perfusion Pressure in Patients with Type 2 Diabetes
- Source :
- Endocrinology and Metabolism, Vol 35, Iss 3, Pp 578-586 (2020), Endocrinology and Metabolism
- Publication Year :
- 2020
- Publisher :
- Academya Publishing Co., 2020.
-
Abstract
- Background Few studies have examined the relationship of sarcopenia with the microcirculation. The current study investigated the relationship of sarcopenia with microcirculatory function, as assessed by skin perfusion pressure (SPP), in type 2 diabetes mellitus (T2DM) patients. Methods In total, 102 T2DM patients who underwent SPP measurements and bioelectrical impedance analysis (BIA) were enrolled in this cross-sectional study. SPP was assessed using the laser Doppler technique. Sarcopenia was defined as low height-adjusted appendicular muscle mass (men, l7 kg/m2; women, l5.7 kg/m2) using BIA. We divided the participants into two groups based on SPP (≤50 and g50 mm Hg), and an SPP below 50 mm Hg was considered to reflect impaired microcirculation. Results Fourteen patients (13.7%) were diagnosed with impaired microcirculatory function of the lower limb based on SPP. The prevalence of sarcopenia in all subjects was 11.8%, but the percentage of patients with an SPP ≤50 mm Hg who had sarcopenia was more than triple that of patients with an SPP g50 mm Hg (28.6% vs. 9.1%, P=0.036). A significant positive correlation was found between SPP and appendicular muscle mass adjusted for height (P=0.041 for right-sided SPP). Multiple logistic regression analysis showed that patients with sarcopenia had an odds ratio of 4.1 (95% confidence interval, 1.01 to 24.9) for having an SPP ≤50 mm Hg even after adjustment for confounding factors. Conclusion These results suggest that sarcopenia may be significantly associated with impaired microcirculation in patients with T2DM. Nonetheless, the small number of patients and wide CI require cautious interpretation of the results.
- Subjects :
- Male
medicine.medical_specialty
skin
Endocrinology, Diabetes and Metabolism
microcirculation
030209 endocrinology & metabolism
Type 2 diabetes
Gastroenterology
lcsh:Diseases of the endocrine glands. Clinical endocrinology
perfusion
Microcirculation
sarcopenia
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal medicine
Diabetes mellitus
Republic of Korea
Laser-Doppler Flowmetry
Humans
Medicine
Muscle, Skeletal
Aged
lcsh:RC648-665
business.industry
Confounding
Odds ratio
Middle Aged
medicine.disease
Confidence interval
Cross-Sectional Studies
Logistic Models
Diabetes Mellitus, Type 2
type 2
030220 oncology & carcinogenesis
Sarcopenia
diabetes mellitus
Original Article
Female
business
Bioelectrical impedance analysis
Subjects
Details
- Language :
- English
- ISSN :
- 20935978
- Volume :
- 35
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Endocrinology and Metabolism
- Accession number :
- edsair.doi.dedup.....e207df3baddf72de707a6346891c0420