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Pancreatic α-cell mass in obesity
- Source :
- Diabetes, Obesity and Metabolism, 19(12), 1810-1813. Wiley-Blackwell
- Publication Year :
- 2017
-
Abstract
- While it is well recognized that obesity is associated with an increased β-cell mass, the association with α-cell mass is less clear. Type 2 diabetes (T2DM) associated with obesity is a bihormonal disease characterized by inadequate insulin secretion and hyperglucagonaemia. We examined β- and α-cell mass throughout the pancreas in obese and lean subjects. Pancreatic tissue of the head, body and tail region of the pancreas was examined from 15 obese subjects (body mass index [BMI] ≥ 27 kg/m2 ) and 15 age-matched lean subjects (BMI ≤ 25 kg/m2 ) without diabetes. In obese subjects both β- and α-cell mass were proportionally higher compared with lean subjects, thereby maintaining the α- to β-cell ratio. The adaptation to obesity occurred preferentially in the head of the pancreas. As data so far have been derived from histological studies of β- and α-cell adaptation, in which the head region of the human pancreas was not included, the adaptive capacity of humans to obesity has previously been underestimated. Obesity is associated with an increased α-cell mass, which could contribute to the hyperglucagonaemia observed in people with T2DM.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Cell Count
030209 endocrinology & metabolism
Disease
Type 2 diabetes
Glucagon
Body Mass Index
03 medical and health sciences
0302 clinical medicine
Endocrinology
Insulin-Secreting Cells
Diabetes mellitus
Internal medicine
Image Processing, Computer-Assisted
Internal Medicine
medicine
Journal Article
Humans
Insulin
Obesity
Cell Proliferation
Cell Size
geography
geography.geographical_feature_category
business.industry
Reproducibility of Results
Organ Size
Middle Aged
medicine.disease
Islet
Immunohistochemistry
Tissue Donors
Ki-67 Antigen
030104 developmental biology
medicine.anatomical_structure
Glucagon-Secreting Cells
Pancreas
business
Body mass index
Subjects
Details
- Language :
- English
- ISSN :
- 14628902
- Volume :
- 19
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Diabetes, Obesity and Metabolism
- Accession number :
- edsair.doi.dedup.....e205ab39834ad28716df591d60f16b03