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Ginsenoside Rb1 Alleviates Oxidative Low-Density Lipoprotein-Induced Vascular Endothelium Senescence via the SIRT1/Beclin-1/Autophagy Axis
- Source :
- Journal of cardiovascular pharmacology. 75(2)
- Publication Year :
- 2019
-
Abstract
- Oxidative low-density lipoprotein (ox-LDL) induces endothelium senescence and promotes atherosclerosis. Ginsenoside Rb1 (gRb1) has been proved to protect human umbilical vein cells (HUVECs), but its effect on ox-LDL-induced endothelium senescence and the underlying mechanism remains unknown. This study is to explore the involvement of the SIRT1/Beclin-1/autophagy axis in the effect of gRb1 on protecting endothelium against ox-LDL-induced senescence. Hyperlipidemia of Sprague Dawley rats was induced by high-fat diet, and gRb1 was intraperitoneal injected. A senescence model of HUVECs induced by ox-LDL was also established. The results showed that gRb1 alleviated hyperlipidemia-induced endothelium senescence and ox-LDL-induced HUVECs senescence. GRb1 also restored the reductions in SIRT1 and autophagy, which were involved in the anti-senescence effects. Beclin-1 acetylation was reduced, and the correlation between SIRT1 and Beclin-1 was increased by gRb1. Results of our study demonstrated the anti-senescence function of gRb1 against hyperlipidemia in the endothelium, and the underlying mechanism involves the SIRT1/Beclin-1/autophagy axis.
- Subjects :
- 0301 basic medicine
Senescence
Male
Endothelium
Ginsenosides
Hyperlipidemias
030204 cardiovascular system & hematology
Diet, High-Fat
Umbilical vein
Rats, Sprague-Dawley
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Sirtuin 1
Hyperlipidemia
medicine
Autophagy
Animals
Humans
Cells, Cultured
Cellular Senescence
Hypolipidemic Agents
Pharmacology
Endothelial Cells
Acetylation
medicine.disease
Cell biology
Lipoproteins, LDL
Disease Models, Animal
030104 developmental biology
medicine.anatomical_structure
chemistry
Low-density lipoprotein
cardiovascular system
lipids (amino acids, peptides, and proteins)
Beclin-1
Signal transduction
Cardiology and Cardiovascular Medicine
Lipoprotein
Signal Transduction
Subjects
Details
- ISSN :
- 15334023
- Volume :
- 75
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of cardiovascular pharmacology
- Accession number :
- edsair.doi.dedup.....e1fdf5d9a60e5b562325576a81675073