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Strong Upregulation of AIM2 and IFI16 Inflammasomes in the Mucosa of Patients with Active Inflammatory Bowel Disease
- Source :
- Inflammatory Bowel Diseases, 21(11), 2673-2682. LIPPINCOTT WILLIAMS & WILKINS
- Publication Year :
- 2015
-
Abstract
- BACKGROUND: Inflammatory bowel disease (IBD) is characterized by a chronic inflammation of the gut, partly driven by defects in the innate immune system. Considering the central role of inflammasome signaling in innate immunity, we studied inflammasome components in IBD mucosa. METHODS: Expression of genes encoding inflammasome sensor subunits was investigated in colonic mucosal biopsies from 2 cohorts of patients with IBD and controls. RESULTS: A significant upregulation (>2-fold change in expression, false discovery rate
- Subjects :
- Adult
Male
Transcriptional Activation
GENE ATG16L1
Inflammasomes
Biopsy
PATHOGENESIS
Caspase 1
Inflammation
Biology
Inflammatory bowel disease
NLRP3 INFLAMMASOME
ACTIVATION
Cohort Studies
AIM2
Intestinal mucosa
Downregulation and upregulation
INFLIXIMAB
medicine
Immunology and Allergy
Humans
HMGB1 Protein
Intestinal Mucosa
METAANALYSIS
Aged
Innate immune system
Gastroenterology
Nuclear Proteins
Inflammasome
Epithelial Cells
DNA
ASSOCIATION
Middle Aged
medicine.disease
Inflammatory Bowel Diseases
Phosphoproteins
digestive system diseases
CROHNS-DISEASE
Immunity, Innate
Up-Regulation
DNA-Binding Proteins
Case-Control Studies
Immunology
AUTOPHAGY
Female
medicine.symptom
medicine.drug
Signal Transduction
Subjects
Details
- ISSN :
- 15364844 and 10780998
- Volume :
- 21
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Inflammatory bowel diseases
- Accession number :
- edsair.doi.dedup.....e1f3dd90bca7a4b3021a7eef57773560