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Enantiomeric Isoflavones with neuroprotective activities from the Fruits of Maclura tricuspidata
- Source :
- Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019), Scientific Reports
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group, 2019.
-
Abstract
- Seven pairs of enantiomeric isoflavones (1a/1b–7a/7b) were obtained from the ethyl acetate extract of the fruits of Maclura tricuspidata (syn. Cudrania tricuspidata), and successfully separated by chiral high-pressure liquid chromatography (HPLC). The structures and absolute configurations of the enantiomeric isoflavones were established on the basic of comprehensive spectroscopic analyses and quantum chemical calculation methods. Compounds 1, 1a, and 1b exhibited neuroprotective activities against oxygen-glucose deprivation/reoxygenation (ODG/R)-induced SH-SY5Y cells death with EC50 values of 5.5 µM, 4.0 µM, and 10.0 µM, respectively. Furthermore, 1, 1a, and 1b inhibited OGD/R-induced reactive oxygen species generation in SH-5Y5Y cells with IC50 values of 6.9 µM, 4.5 µM, and 9.5 µM, respectively.
- Subjects :
- 0301 basic medicine
Magnetic Resonance Spectroscopy
Maclura
Phytochemicals
Ethyl acetate
lcsh:Medicine
High-performance liquid chromatography
Neuroprotection
Article
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Cell Line, Tumor
Humans
Maclura tricuspidata
lcsh:Science
EC50
Multidisciplinary
Chromatography
Cell Death
Molecular Structure
biology
Plant Extracts
Chemistry
lcsh:R
Nuclear magnetic resonance spectroscopy
Isoflavones
biology.organism_classification
Neuroprotective Agents
030104 developmental biology
Fruit
lcsh:Q
Enantiomer
Reactive Oxygen Species
030217 neurology & neurosurgery
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....e1dc1d24e953777c9d92ad969069d6d4