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Salvage Therapies After 18F-Fluciclovine Detected Prostate Cancer Recurrences
- Source :
- Clinical Nuclear Medicine. 45:668-671
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Background F-Fluciclovine is the most recent prostate cancer (PCa)-directed PET radiotracer approved by the US Food and Drug Administration for detection of recurrent PCa. We report the treatments and outcomes of patients at our institution with PCa recurrences detected on F-fluciclovine PET/CT. Methods We identified men with recurrent PCa detected on F-fluciclovine PET/CT performed between 2017 and 2018 who were previously treated definitively and analyzed their patterns of care and cancer-specific outcomes. Results We identified 28 men with recurrent PCa detected on F-fluciclovine PET/CT. Twenty-three were initially treated with surgery and 13 also received postoperative radiation therapy (RT). Five patients were initially treated with definitive radiation. After surgery, the median time to F-fluciclovine PET/CT was 67 months (median prostate-specific antigen [PSA] of 1.63 ng/mL). After RT, the median time to F-fluciclovine PET/CT was 95 months with median PSA of 13.31 ng/mL. Six men recurred locally, 9 recurred in the pelvic nodes, 9 had distant nodal recurrences, and 4 had osseous metastases. Of the patients initially treated with surgery, 4 received salvage radiation and 3 received androgen deprivation therapy (ADT). Of the patients initially treated with surgery and postoperative RT, 3 received salvage pelvic nodal dissection, 4 received salvage radiation, and 2 received ADT. Of the patients initially treated with radiation, 4 received salvage ADT. All had PSA decline after salvage therapy. Conclusions F-fluciclovine PET/CT can localize PCa recurrences, and subsequent salvage therapies appear effective with decreasing PSA. Longer follow-up will reveal if these diagnostic tests and subsequent therapies will improve PCa survival.
- Subjects :
- Male
medicine.medical_specialty
Carboxylic Acids
Salvage therapy
Bone Neoplasms
030218 nuclear medicine & medical imaging
Androgen deprivation therapy
Food and drug administration
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Recurrence
Positron Emission Tomography Computed Tomography
medicine
Humans
Radiology, Nuclear Medicine and imaging
Aged
Salvage Therapy
Patterns of care
business.industry
Postoperative radiation
Prostatic Neoplasms
Androgen Antagonists
General Medicine
Middle Aged
medicine.disease
Dissection
030220 oncology & carcinogenesis
Radiology
Previously treated
business
Cyclobutanes
Subjects
Details
- ISSN :
- 15360229 and 03639762
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Clinical Nuclear Medicine
- Accession number :
- edsair.doi.dedup.....e1d50efcc3f5328a897a68493b12b7b6