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Small Bowel Preparations for Capsule Endoscopy With Mannitol and Simethicone
- Source :
- Journal of Clinical Gastroenterology. 45:337-341
- Publication Year :
- 2011
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2011.
-
Abstract
- Background and objective There is no consensus concerning small bowel preparation before capsule endoscopy (CE). This study evaluated the effects of 4 regimens on small bowel cleansing and diagnostic yield. Methods Patients were randomly divided into 4 groups. Group A consumed a clear liquid diet after lunch on the day before CE, followed by overnight fasting. Group B took 250 mL 20% mannitol and 1 L 0.9% saline orally at 05:00 hours on the day of the procedure. In group C, the same regimen was taken at 20:00 hours on the day before and at 05:00 hours on the day of CE. In group D, in addition to the group C regimen, 20 mL oral simethicone was taken 30 minutes before CE. Results Two hundred patients were prospectively enrolled, and 7 were excluded from the final analysis because of incomplete small bowel transit. No significant difference was noted among the 4 groups for small bowel transit time. Bowel preparation in group D was significantly better than for the other regimens for overall cleansing of the proximal small bowel, and showed improved overall cleansing of the distal small bowel when compared with 10-hours overnight fasting. Pathological lesions of the proximal and distal small bowel were, respectively, achieved in 82 and 74 patients, mostly distributed in group D. Conclusions Small bowel preparation that involves split-dose oral mannitol plus single-dose simethicone for CE can improve mucosal visualization and subsequent diagnostic yield when compared with 10-hours overnight fasting.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Premedication
medicine.medical_treatment
Administration, Oral
Antifoaming Agents
Capsule Endoscopy
Gastroenterology
Drug Administration Schedule
law.invention
Young Adult
Randomized controlled trial
law
Capsule endoscopy
Internal medicine
Intestine, Small
Simethicone
Humans
Medicine
Mannitol
Prospective Studies
Gastrointestinal Transit
Therapeutic Irrigation
Prospective cohort study
Saline
Aged
Aged, 80 and over
Dose-Response Relationship, Drug
business.industry
digestive, oral, and skin physiology
Middle Aged
Diuretics, Osmotic
Small intestine
Surgery
Regimen
Treatment Outcome
medicine.anatomical_structure
Female
Diuretic
business
Subjects
Details
- ISSN :
- 01920790
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Gastroenterology
- Accession number :
- edsair.doi.dedup.....e1cbb521e1d48265d8a630f256272d64