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Maturation of bone marrow-derived dendritic cells by a novel β-glucan purified from Paenibacillus polymyxa JB115
- Source :
- Journal of Veterinary Science
- Publication Year :
- 2011
-
Abstract
- We investigated the immunostimulatory effects of a novel β-glucan purified from Paenibacillus (P.) polymyxa JB115 on bone marrow-derived dendritic cells (DCs), a type of potent antigen-presenting cells. β-glucan isolated from P. polymyxa JB115 enhanced the viability and induced the maturation of DCs. β-glucan markedly increased the cytokine production of DCs and surface expression of DC markers. In addition, DCs treated with β-glucan showed a higher capacity to stimulate allogeneic spleen cell proliferation compared to those treated with medium alone. These results demonstrate the effect of β-glucan on DC maturation and may increase the use of β-glucan.
- Subjects :
- beta-Glucans
Cell Survival
medicine.medical_treatment
Short Communication
Bone Marrow Cells
β-glucan
macromolecular substances
Nitric Oxide
Flow cytometry
Microbiology
Immunophenotyping
Paenibacillus
Mice
medicine
Animals
Glucan
chemistry.chemical_classification
Mice, Inbred BALB C
General Veterinary
biology
medicine.diagnostic_test
Tumor Necrosis Factor-alpha
maturation
Dendritic Cells
JB115
biology.organism_classification
Flow Cytometry
Interleukin-12
carbohydrates (lipids)
stomatognathic diseases
medicine.anatomical_structure
Cytokine
chemistry
Interleukin 12
Paenibacillus polymyxa
Bone marrow
Subjects
Details
- ISSN :
- 1976555X
- Volume :
- 12
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of veterinary science
- Accession number :
- edsair.doi.dedup.....e1c3fcf79da025567815d1e380fa288a