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Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2
- Source :
- Nature communications
- Publication Year :
- 2014
- Publisher :
- Springer Science and Business Media LLC, 2014.
-
Abstract
- It is unclear how CD4 T cell memory formation is regulated following pathogen challenge, and when critical mechanisms act to determine effector T cell fate. Here, we report that following influenza infection most effectors require signals from major histocompatibility complex class II molecules and CD70 during a late window well after initial priming to become memory. During this timeframe, effector cells must produce IL-2 or be exposed to high levels of paracrine or exogenously added IL-2 to survive an otherwise rapid default contraction phase. Late IL-2 promotes survival through acute down regulation of apoptotic pathways in effector T cells and by permanently upregulating their IL-7 receptor expression, enabling IL-7 to sustain them as memory T cells. This new paradigm defines a late checkpoint during the effector phase at which cognate interactions direct CD4 T cell memory generation.
- Subjects :
- CD4-Positive T-Lymphocytes
Male
Interleukin 2
Receptor expression
Genes, MHC Class II
Mice, Nude
General Physics and Astronomy
Priming (immunology)
Apoptosis
Biology
Autocrine Communication
Article
General Biochemistry, Genetics and Molecular Biology
Interleukin-7 Receptor alpha Subunit
03 medical and health sciences
Paracrine signalling
0302 clinical medicine
Downregulation and upregulation
medicine
Animals
Autocrine signalling
030304 developmental biology
Mice, Inbred BALB C
0303 health sciences
Multidisciplinary
Effector
Interleukin-7
General Chemistry
Tumor Necrosis Factor Receptor Superfamily, Member 7
Cell biology
Mice, Inbred C57BL
Influenza A virus
Immunology
Interleukin-2
Female
Immunologic Memory
CD27 Ligand
030215 immunology
medicine.drug
Subjects
Details
- ISSN :
- 20411723
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....e1bf23420f5ab5d31da7875d2e041352