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Acute Recanalization of Large Vessel Occlusion in the Anterior Circulation Stroke: Is Mechanical Thrombectomy Alone Better in Patients over 80 Years of Age? Findings from a Retrospective Observational Study
- Source :
- Journal of Clinical Medicine, Vol 10, Iss 4266, p 4266 (2021), Journal of Clinical Medicine, Volume 10, Issue 18
- Publication Year :
- 2021
- Publisher :
- MDPI AG, 2021.
-
Abstract
- Real-world data report worse 3-month clinical outcomes in elderly patients with acute ischemic stroke (AIS) treated with mechanical thrombectomy (MT). The aim was to identify factors influencing clinical outcome in elderly patients with anterior circulation AIS treated with MT (±intravenous thrombolysis (IVT)). In a retrospective, monocentric study, analysis of prospectively collected data of 138 patients (≥80 years) was performed. IVT was an independent negative predictor (OR 0.356<br />95% CI: 0.134–0.942) and female sex an independent positive predictor (OR 4.179, 95% CI: 1.300–13.438) of 3-month good clinical outcome (modified Rankin scale 0–2). Female sex was also an independent negative predictor of 3-month mortality (OR 0.244, 95% CI: 0.100–0.599). Other independent negative predictors of 3-month good clinical outcome were older age, lower pre-stroke self-sufficiency, more severe neurological deficit and longer procedural intervals. Mortality was also independently predicted by longer procedural interval and by the occurrence of symptomatic intracerebral hemorrhage (p &lt<br />0.05 in all cases). Our results demonstrated, that in patients aged ≥80 years with anterior circulation AIS undergoing MT (±IVT), IVT reduced the chance of 3-month good clinical outcome and female sex was associated with a greater likelihood of 3-month good clinical outcome and lower probability of 3-month mortality.
- Subjects :
- medicine.medical_specialty
acute ischemic stroke
bridging therapy
medicine.medical_treatment
clinical outcome
elderly patients
recanalization
Article
mechanical thrombectomy
Modified Rankin Scale
Internal medicine
large vessel occlusion
medicine
In patient
intravenous thrombolysis
Stroke
Intracerebral hemorrhage
business.industry
Retrospective cohort study
General Medicine
Thrombolysis
medicine.disease
humanities
Mechanical thrombectomy
anterior circulation
Medicine
business
Large vessel occlusion
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Volume :
- 10
- Issue :
- 4266
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....e1b47161bbf12be045e87f891cc80927