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Re-evaluation of progenitor thresholds and expectations for haematopoietic recovery based on an analysis of 810 autologous transplants: Implications for quality assurance
- Source :
- British Journal of Haematology. 175:673-676
- Publication Year :
- 2016
- Publisher :
- Wiley, 2016.
-
Abstract
- Haematological engraftment was assessed in 804 autologous transplants. Neutrophil recovery occurred in over 99% within 14 d but platelet recovery was delayed beyond this time in 14·8%. Time to recovery was dependent on the progenitor cell dose infused. The minimum CD34+ cell threshold adopted in this study (2 × 106 /kg) was safe although recovery was faster with a dose >5 × 106 /kg. CD34+ cell doses of between 1 and 2 × 106 /kg were also acceptable if either the granulocyte-macrophage colony-forming cell dose exceeded 2 × 105 /kg or this dose was due to splitting a higher yield harvest. Prompt neutrophil recovery affords important quality assurance for laboratory processing.
- Subjects :
- Adult
Male
Time Factors
Transplantation Conditioning
Adolescent
Quality Assurance, Health Care
Cell
CD34
030204 cardiovascular system & hematology
Transplantation, Autologous
Andrology
Young Adult
03 medical and health sciences
0302 clinical medicine
Cell dose
Humans
Medicine
Progenitor cell
Aged
Progenitor
business.industry
Platelet recovery
Graft Survival
Hematopoietic Stem Cell Transplantation
Hematology
Middle Aged
Hematopoietic Stem Cells
Blood Cell Count
Hematopoiesis
Haematopoiesis
Treatment Outcome
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
business
Quality assurance
Subjects
Details
- ISSN :
- 00071048
- Volume :
- 175
- Database :
- OpenAIRE
- Journal :
- British Journal of Haematology
- Accession number :
- edsair.doi.dedup.....e1a27e01b30076551e15e8055d1efb69
- Full Text :
- https://doi.org/10.1111/bjh.14276