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Re-evaluation of progenitor thresholds and expectations for haematopoietic recovery based on an analysis of 810 autologous transplants: Implications for quality assurance

Authors :
Andrew Antonio
David C. Linch
Michael J. Watts
Simon Hack
Carmen Balsa
SJ Ings
Source :
British Journal of Haematology. 175:673-676
Publication Year :
2016
Publisher :
Wiley, 2016.

Abstract

Haematological engraftment was assessed in 804 autologous transplants. Neutrophil recovery occurred in over 99% within 14 d but platelet recovery was delayed beyond this time in 14·8%. Time to recovery was dependent on the progenitor cell dose infused. The minimum CD34+ cell threshold adopted in this study (2 × 106 /kg) was safe although recovery was faster with a dose >5 × 106 /kg. CD34+ cell doses of between 1 and 2 × 106 /kg were also acceptable if either the granulocyte-macrophage colony-forming cell dose exceeded 2 × 105 /kg or this dose was due to splitting a higher yield harvest. Prompt neutrophil recovery affords important quality assurance for laboratory processing.

Details

ISSN :
00071048
Volume :
175
Database :
OpenAIRE
Journal :
British Journal of Haematology
Accession number :
edsair.doi.dedup.....e1a27e01b30076551e15e8055d1efb69
Full Text :
https://doi.org/10.1111/bjh.14276