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Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection
- Source :
- Cell. 185:4190-4205.e25
- Publication Year :
- 2022
- Publisher :
- Elsevier BV, 2022.
-
Abstract
- Neuroepithelial crosstalk is critical for gut physiology. However, the mechanisms by which sensory neurons communicate with epithelial cells to mediate gut barrier protection at homeostasis and during inflammation are not well understood. Here, we find that Nav1.8
Details
- ISSN :
- 00928674
- Volume :
- 185
- Database :
- OpenAIRE
- Journal :
- Cell
- Accession number :
- edsair.doi.dedup.....e1992823b2d50000e0b168af617b75fd
- Full Text :
- https://doi.org/10.1016/j.cell.2022.09.024