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Intraocular Concentrations of Growth Factors and Cytokines in Retinal Vein Occlusion and the Effect of Therapy with Bevacizumab
- Source :
- Investigative Opthalmology & Visual Science. 50:1025
- Publication Year :
- 2009
- Publisher :
- Association for Research in Vision and Ophthalmology (ARVO), 2009.
-
Abstract
- Purpose To investigate concentrations of growth factors and inflammatory cytokines in eyes with central (CRVO) and branch (BRVO) retinal vein occlusion before and during therapy with bevacizumab and to identify associations with disease activity. Methods In a prospective clinical trial, 13 eyes of patients with CRVO (n = 5) or BRVO (n = 8) were included. Bevacizumab was administered intravitreously at baseline and months 1 and 2. Retreatments were given at monthly visits if OCT showed edema or when vision loss occurred. Aqueous humor samples were taken each time injections were performed. Follow-up was 15 months. Samples from patients with cataract served as the control. Multiplex bead assays were used for measurement of 28 growth factors and cytokines. Results During therapy with bevacizumab, VEGF levels were reduced to below detection in the first 2 months. Whenever criteria for retreatment were met, VEGF was measurable again. The decrease in VEGF was associated with a decrease in central retinal thickness (CRT) and improvement in visual acuity (VA). Significantly increased concentrations of VEGF, IL-6, IL-8, IP-10, MCP-1, and PDGF-AA were observed in aqueous humor samples of patients with CRVO compared with the control samples. Conclusions VEGF levels were significantly elevated in patients with CRVO compared with control subjects. Intravitreal injections of bevacizumab resulted in a substantial decrease of VEGF under physiologic levels and remained low under the loading dose of three consecutive monthly retreatments. Macular edema was related to VEGF levels in the aqueous humor.
- Subjects :
- Vascular Endothelial Growth Factor A
medicine.medical_specialty
Visual acuity
genetic structures
Bevacizumab
Angiogenesis Inhibitors
Antibodies, Monoclonal, Humanized
Loading dose
Macular Edema
Injections
Aqueous Humor
chemistry.chemical_compound
Central retinal vein occlusion
Ophthalmology
Edema
Retinal Vein Occlusion
medicine
Humans
Prospective Studies
Macular edema
Aged
business.industry
Antibodies, Monoclonal
Retinal
Middle Aged
medicine.disease
eye diseases
Surgery
Vitreous Body
chemistry
Cytokines
Intercellular Signaling Peptides and Proteins
sense organs
medicine.symptom
business
Biomarkers
Tomography, Optical Coherence
medicine.drug
Retinopathy
Subjects
Details
- ISSN :
- 15525783
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Investigative Opthalmology & Visual Science
- Accession number :
- edsair.doi.dedup.....e18f44b7f4019bc4662a7339c9198ff3