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NT, NPY and PGP 9.5 presence in myomeytrium and in fibroid pseudocapsule and their possible impact on muscular physiology
- Source :
- Gynecological Endocrinology. 29:177-181
- Publication Year :
- 2012
- Publisher :
- Informa UK Limited, 2012.
-
Abstract
- The uterine myoma pseudocapsule is a neurovascular bundle surrounding fibroid, containing neuropeptides, probably involved in uterine scar healing. We studied neurotensin (NT), neuropeptide tyrosine (NPY), and protein gene product 9.5 (PGP 9.5) nerve fibres in the pseudocapsule neurovascular bundle of intramural uterine fibroids on 67 no pregnant women by intracapsular myomectomy sparing the neurovascular bundle, sampling full thickness specimens of the pseudocapsule of uterine fibroids (PUF) and normal myometrium (NM) obtained from the fundus uteri (FU) and the uterine body (UB). The samples were sent for histological and immunofluorescent analyses and compared by morphometrical quantification. The Conventional Unit (C.U.) difference of NT, NPY, and PGP 9.5 nerve fibres was statistically analyzed. Our results showed that NT, NPY, and PGP 9.5 neurofibers are almost equally present in PUF as in NM of a no pregnant uterus. As all of these neuropeptides are present in the uterine muscle and can affect muscle contractility, uterine peristalsis and muscular healing. A myomectomy respecting the pseudocapsule neurofibers should facilitate smooth muscle scarring and promote restoration of normal uterine peristalsis with a possible positive influence on fertility.
- Subjects :
- Endocrinology, Diabetes and Metabolism
Uterine contraction
Hospitals, University
Uterine Contraction
chemistry.chemical_compound
Nerve Fibers
Endocrinology
Japan
Medicine
Neuropeptide Y
Prospective Studies
Neurotensin
Leiomyoma
Myometrium
Obstetrics and Gynecology
Uterine myoma
Immunohistochemistry
female genital diseases and pregnancy complications
Italy
Uterine Neoplasms
Female
medicine.symptom
Ubiquitin Thiolesterase
Adult
medicine.medical_specialty
Uterine fibroids
Neuropeptide
neurovascular bundle
reproduction
Contractility
Leiomyomatosis
Internal medicine
Uterine Myomectomy
Humans
myomectomy
uterine scar
business.industry
medicine.disease
Neurovascular bundle
muscle injuries and repair
pseudocapsule
chemistry
fibroid
business
Organ Sparing Treatments
Biomarkers
Subjects
Details
- ISSN :
- 14730766 and 09513590
- Volume :
- 29
- Database :
- OpenAIRE
- Journal :
- Gynecological Endocrinology
- Accession number :
- edsair.doi.dedup.....e185bc8aceeb4784dfc5f792fa2561c7