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A Psychosocial Genomics Pilot Study in Oncology for Verifying Clinical, Inflammatory and Psychological Effects of Mind-Body Transformations-Therapy (MBT-T) in Breast Cancer Patients: Preliminary Results
- Source :
- Journal of Clinical Medicine, Volume 10, Issue 1, Journal of Clinical Medicine, Vol 10, Iss 136, p 136 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Several studies have highlighted the key role of chronic inflammation in breast cancer development, progression, metastasis, and therapeutic outcome. These processes are mediated through a variety of cytokines and hormones that exert their biological actions either locally or distantly via systemic circulation. Recent findings suggest that positive psychosocial experiences, including psychotherapeutic interventions and therapeutic mind-body protocols, can modulate the inflammatory response by reducing the expression of genes/proteins associated with inflammation and stress-related pathways. Our preliminary results indicate that a specific mind-body therapy (MBT-T) could induce a significant reduction of the release of different cytokines and chemokines, such as SCGF&beta<br />SDF-1&alpha<br />MCP3, GRO&alpha<br />LIF, and IL-18, in the sera of breast cancer patients compared to a control group, suggesting that MBT-T could represent a promising approach to improve the wellness and outcome of breast cancer patients.
- Subjects :
- 0301 basic medicine
Oncology
medicine.medical_specialty
Chemokine
lcsh:Medicine
Inflammation
Psychosocial Genomics
mind-body transformations therapy (MBT-T)
Systemic circulation
Article
Metastasis
breast cancer
inflammation
cytokines, psychosocial genomics
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
cytokine
medicine
psychosocial genomics
biology
business.industry
lcsh:R
Settore M-PSI/03 - Psicometria
General Medicine
medicine.disease
cytokines
030104 developmental biology
030220 oncology & carcinogenesis
biology.protein
medicine.symptom
business
Psychosocial
Hormone
Subjects
Details
- Language :
- English
- ISSN :
- 20770383
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Medicine
- Accession number :
- edsair.doi.dedup.....e179a2ad98c4908487c4c0cf6d158c38
- Full Text :
- https://doi.org/10.3390/jcm10010136