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Functional connectivity of the thalamocortical circuit in patients with seizure relapse after antiseizure medication withdrawal
- Source :
- Epilepsia. 62:2463-2473
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- OBJECTIVE To characterize the features of thalamocortical functional connectivity during seizure recurrence at the time of antiseizure medication (ASM) withdrawal. METHODS Patients with chronic epilepsy who attempted to discontinue medications were prospectively registered and followed up; 19 patients remained seizure-free (SF-group), 18 patients had seizure relapses (SR-group) after ASM withdrawal, and 28 healthy controls were recruited. Resting-state functional magnetic resonance imaging was performed before ASM withdrawal. Thalamus subdivisions were set as seeds to calculate voxelwise functional connectivity. Partial correlation analysis between functional connectivity and clinical variables was performed. A support vector machine was used to assess the predictive ability of the specific functional connectivity for seizure relapse. RESULTS The within-group comparison indicated that the SR-group had more extensive functional connectivity than the SF-group; the left inferior pulvinar, left medial pulvinar, and right anterior pulvinar showed a significantly stronger functional connection with the precuneus in the SR-group than in the SF-group (Gaussian random field correction, voxel-level p
- Subjects :
- medicine.medical_specialty
Thalamus
Precuneus
Epilepsy
Recurrence
Seizures
Internal medicine
medicine
Humans
In patient
medicine.diagnostic_test
business.industry
Functional connectivity
Area under the curve
medicine.disease
Magnetic Resonance Imaging
Substance Withdrawal Syndrome
medicine.anatomical_structure
Neurology
Cardiology
Neurology (clinical)
Functional magnetic resonance imaging
business
Right anterior
Subjects
Details
- ISSN :
- 15281167 and 00139580
- Volume :
- 62
- Database :
- OpenAIRE
- Journal :
- Epilepsia
- Accession number :
- edsair.doi.dedup.....e16fb1f66299974b8964d5b50bc70bd3