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Dark coffee consumption protects human blood cells from spontaneous DNA damage
- Source :
- Journal of Functional Foods, Vol 55, Iss, Pp 285-295 (2019)
- Publication Year :
- 2019
- Publisher :
- Elsevier, 2019.
-
Abstract
- Coffee increasingly attracts notice with respect to beneficial health effects. Our objective was to investigate DNA protective effects of a special roast coffee blend of pure Arabica (Coffea arabica L.) in healthy volunteers (n = 96), following a prospective, randomized, controlled study with parallel design (coffee versus water). Potential modulation of Nrf2 signaling was evaluated by focusing on its two master regulators, Nrf2 and Keap1, as well as on Nrf2 translocation in the volunteers’ lymphocytes (PBLs). In this context a newly established fluorescence imaging method for Nrf2 translocation analysis in PBLs turned out as feasible and eligible tool applicable for future studies. After chronical coffee consumption (8 weeks) spontaneous DNA strand breaks were significantly lower in the coffee group compared to water control, suggesting a protective effect of the coffee blend. Nrf2 signaling was remotely affected, indicating that additional mechanisms of protection from DNA damage need to be considered.
- Subjects :
- 0301 basic medicine
Keap1
Future studies
DNA damage
Medicine (miscellaneous)
Chromosomal translocation
Coffee consumption
Context (language use)
Biology
Pharmacology
Coffee
Nrf2
03 medical and health sciences
0404 agricultural biotechnology
TX341-641
030109 nutrition & dietetics
Nutrition and Dietetics
Human blood
Nutrition. Foods and food supply
Coffea arabica
human PBLs
04 agricultural and veterinary sciences
respiratory system
040401 food science
DNA integrity
Food Science
Nrf2 signaling
Subjects
Details
- Language :
- English
- ISSN :
- 17564646
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Journal of Functional Foods
- Accession number :
- edsair.doi.dedup.....e162d18345c0671489f45ef5a6681ceb