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Allergic Bronchopulmonary Aspergillosis in Asthma and Cystic Fibrosis
- Source :
- Clinical and Developmental Immunology, Vol 2011 (2011), Clinical and Developmental Immunology
- Publication Year :
- 2011
- Publisher :
- Hindawi Limited, 2011.
-
Abstract
- Allergic bronchopulmonary aspergillosis (ABPA) is a Th2 hypersensitivity lung disease in response toAspergillus fumigatusthat affects asthmatic and cystic fibrosis (CF) patients. Sensitization toA. fumigatusis common in both atopic asthmatic and CF patients, yet only 1-2% of asthmatic and 7–9% of CF patients develop ABPA. ABPA is characterized by wheezing and pulmonary infiltrates which may lead to pulmonary fibrosis and/or bronchiectasis. The inflammatory response is characterized by Th2 responses toAspergillusallergens, increased serum IgE and eosinophilia. A number of genetic risks have recently been identified in the development of ABPA. These include HLA-DR and HLA-DQ, IL-4 receptor alpha chain (IL-4RA) polymorphisms, IL-10-1082GA promoter polymorphisms, surfactant protein A2 (SP-A2) polymorphisms, and cystic fibrosis transmembrane conductance regulator gene (CFTR) mutations. The studies indicate that ABPA patients are genetically at risk to develop skewed and heightened Th2 responses toA. fumigatusantigens. These genetic risk studies and their consequences of elevated biologic markers may aid in identifying asthmatic and CF patients who are at risk to the development of ABPA. Furthermore, these studies suggest that immune modulation with medications such as anti-IgE, anti-IL-4 and/or IL-13 monoclonal antibodies may be helpful in the treatment of ABPA.
- Subjects :
- lcsh:Immunologic diseases. Allergy
Cystic Fibrosis
Immunology
Review Article
Aspergillosis
Cystic fibrosis
Aspergillus fumigatus
Pulmonary fibrosis
medicine
Immunology and Allergy
Humans
Biologic marker
Bronchiectasis
biology
business.industry
Aspergillosis, Allergic Bronchopulmonary
General Medicine
medicine.disease
biology.organism_classification
Prognosis
Cystic fibrosis transmembrane conductance regulator
Asthma
biology.protein
Pulmonary Aspergillosis
Allergic bronchopulmonary aspergillosis
business
lcsh:RC581-607
Subjects
Details
- Language :
- English
- ISSN :
- 17402530 and 17402522
- Volume :
- 2011
- Database :
- OpenAIRE
- Journal :
- Clinical and Developmental Immunology
- Accession number :
- edsair.doi.dedup.....e15be448c51e97414e401e8a93e03564