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Modulation of the cardiovascular system by leptin
- Source :
- Biochimie. 94:2097-2103
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- It is well established that individuals with the metabolic syndrome have a significantly increased risk of cardiovascular disease and much effort has been expended to elicit the underlying mechanisms. Various studies have proposed that excessive or deficient physiological effects mediated by leptin make an important contribution, yet many paradoxical observations often preclude a clear definition of the role of leptin. This review article will briefly discuss principal and most recent evidence on direct and indirect regulation of the cardiovascular system by leptin, focusing on cardiac structural and functional as well as vascular effects.
- Subjects :
- Leptin
medicine.medical_specialty
Leptin Deficiency
business.industry
Myocardium
Myocardium metabolism
General Medicine
Disease
medicine.disease
Cardiovascular System
Biochemistry
Obesity
Review article
Endocrinology
Increased risk
Cardiovascular Diseases
Internal medicine
Animals
Blood Vessels
Humans
Medicine
Metabolic syndrome
business
Neuroscience
Subjects
Details
- ISSN :
- 03009084
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Biochimie
- Accession number :
- edsair.doi.dedup.....e1542aeea8df9ca41e5834797ff75986