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Reduction of ipsilateral thalamic volume in temporal lobe epilepsy with hippocampal sclerosis
- Source :
- Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. 55
- Publication Year :
- 2017
-
Abstract
- The thalamus plays an important role in the modulation of both focal and generalized seizures, but the mechanisms related to seizures may be different among epilepsy syndromes. The aim of this study is to investigate the thalamic atrophy in different epilepsy syndromes. We enrolled a total of 72 patients with epilepsy (22 patients with temporal lobe epilepsy with hippocampal sclerosis, 21 patients with extra-temporal lobe epilepsy, and 29 patients with juvenile myoclonic epilepsy). We analyzed structural volumes of the brain with FreeSurfer 5.1 software, and compared them among subgroups of epilepsy and normal control subjects. Moreover, we quantified correlations between the duration of epilepsy and the structural volumes with age and sex as covariates. The volumes of the ipsilateral hippocampus in temporal lobe epilepsy with hippocampal sclerosis were significantly smaller than those in extra-temporal lobe epilepsy and normal control subjects [analysis of variance (ANOVA), p 0.001]. Although the volumes of the ipsilateral thalamus were not different from those of normal control subjects, the volumes of the ipsilateral thalamus were negatively correlated with duration of epilepsy in temporal lobe epilepsy with hippocampal sclerosis (r = -0.5, p = 0.02). However, the volumes of interest in extra-temporal lobe epilepsy and juvenile myoclonic epilepsy were not different from those in normal control subjects, and none of these structures were correlated with duration of epilepsy. These findings suggest that the role of the thalamus may be different in thalamo-limbic circuits among epilepsy syndromes.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
Hippocampus
Temporal lobe
03 medical and health sciences
Epilepsy
0302 clinical medicine
Atrophy
Thalamus
Physiology (medical)
Internal medicine
medicine
Humans
Hippocampal sclerosis
Sclerosis
business.industry
General Medicine
Middle Aged
medicine.disease
Magnetic Resonance Imaging
Lobe
030104 developmental biology
medicine.anatomical_structure
Neurology
Epilepsy, Temporal Lobe
Epilepsy syndromes
Cardiology
Surgery
Female
Neurology (clinical)
Juvenile myoclonic epilepsy
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15322653
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
- Accession number :
- edsair.doi.dedup.....e152068452e094fb9ae90a4d500416ba