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Mechanistic understanding of PtyroneTM: A plant based natural anti diabetic product

Authors :
Malik M. Ahmad
Mohammed H. Geesi
Pravej Alam
Sapana Sameer Chaudhary
Sakshi Rawat
Mohammed H. Alqarni
Sameer Chaudhary
Yogesh A. Dound
Source :
Journal of King Saud University: Science, Vol 33, Iss 5, Pp 101454-(2021)
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Objective To investigate the combinatorial effect of hydroalcoholic extracts of Andrographis paniculata Nees. and Pterocarpus marsupium Roxb. plants prospective to diabetes management. Methods Taking a lead from the scientific literature, in silico studies have also been designed for the screening of anti-diabetic targets against andrographolide and pterostilbene compounds followed by in vivo studies from Andrographis paniculata Nees. and Pterocarpus marsupium Roxb. Furthermore, the diabetes was induced by STZ model and the impact of Andrographis paniculata Nees. and Pterocarpus marsupium Roxb. have been conformed by relative expression studies by qPCR. Results Our results have shown that andrographolide and pterostilbene are SGLT2 inhibitors and selective PPARγ agonists in in silico studies. Later, during in vivo mRNA expression studies confirming the same pattern. The findings of the study has shown to overcome the common knowledge of the only C–glycoside based molecules inhibiting the SGLT2. Conclusions The possible mechanism for PtyroneTM in the management of diabetes could be a selective PPARγ agonist, GLUT4 translocation and SGLT2 inhibition molecule.

Details

ISSN :
10183647
Volume :
33
Database :
OpenAIRE
Journal :
Journal of King Saud University - Science
Accession number :
edsair.doi.dedup.....e14b6d5461d5ad8710e293c7bac7823b
Full Text :
https://doi.org/10.1016/j.jksus.2021.101454