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Real-Time Dissecting the Dynamics of Drug Transportation in the Live Brain
- Source :
- Nano letters. 21(1)
- Publication Year :
- 2020
-
Abstract
- Brain diseases are becoming a more and more serious threat to human health. Many critical properties of the transport mechanisms of drugs in live brains remain poorly understood. In this work, single-particle tracking was used to dissect the transport dynamics of wheat germ agglutinin (WGA) in live brain and characterize the geometry and rheology of the extracellular space (ECS). The results revealed that the movements of WGA were influenced by the specific-binding molecules and the nature of the ECS. We further analyzed the mobility behaviors of WGA globally and quantitatively and found that movement of WGA in brain cells of acute slices was an active transport process associated with actin filaments and microtubules. This work paves the way for studies aiming at characterizing the biophysics of drug transport in the context of live brains, which may contribute to developing potential new therapeutic applications for brain diseases.
- Subjects :
- Drug
Wheat Germ Agglutinins
Mechanical Engineering
media_common.quotation_subject
Transport dynamics
Brain
Bioengineering
Context (language use)
Biological Transport
02 engineering and technology
General Chemistry
Biology
021001 nanoscience & nanotechnology
Condensed Matter Physics
Wheat germ agglutinin
Human health
Pharmaceutical Preparations
Single-particle tracking
Humans
General Materials Science
0210 nano-technology
Extracellular Space
Neuroscience
media_common
Drug transport
Subjects
Details
- ISSN :
- 15306992
- Volume :
- 21
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nano letters
- Accession number :
- edsair.doi.dedup.....e14446604a909c54e8dfc6a3f4185ad4