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Investigating patient acceptability of stratified medicine for schizophrenia : a mixed methods study
- Source :
- Schizophrenia Bulletin Open
- Publication Year :
- 2021
- Publisher :
- Oxford University Press, 2021.
-
Abstract
- Background Health services have advocated a stratified medicine approach in mental health, but little is known about whether service users would accept this approach. Aims To explore service users’ views of the acceptability of stratified medicine for treatment-resistant schizophrenia compared to the traditional “trial-and-error” approach. Methods A mixed methods observational study that explored questionnaire responses on acceptability and whether these responses were affected by demographic or clinical variables. We also investigated whether treatment responsiveness or experience of invasive tests (brain scans and blood tests) affected participants’ responses. Questionnaire generated qualitative data were analyzed thematically. Participants (N108) were aged 18–65, had a diagnosis of schizophrenia, and were adherent to antipsychotic medication. Results Acceptability of a stratified approach was high, even after participants had experienced invasive tests. Most rated it as safer (62% vs 43%; P < .01 [CI: −1.69 to 2.08]), less risky (77% vs 44%; P < .01 [CI: −1.75 to 1.10]), and less painful (90% vs 73%; P < 0.01 [CI: −0.84 to 0.5]) and this was not affected by treatment responsiveness or test experience. Although not statistically significant, treatment nonresponders were more willing to undergo invasive tests. Qualitatively, all participants raised concerns about the risks, discomfort, and potential side effects associated with the invasive tests. Conclusions Service users were positive about a stratified approach for choosing treatments but were wary of devolving clinical decisions to purely data-driven algorithms. These results reinforce the value of service user perspectives in the development and evaluation of novel treatment approaches.
- Subjects :
- medicine.medical_specialty
RM
Schizophrenia (object-oriented programming)
03 medical and health sciences
Health services
0302 clinical medicine
Stratified medicine
Neuroimaging
precision psychiatry
Medicine
030212 general & internal medicine
Psychiatry
neuroimaging
AcademicSubjects/MED00800
business.industry
030503 health policy & services
Mental health
R1
Psychiatry and Mental health
adult psychiatry
0305 other medical science
business
RA
mental health
treatment-resistant schizophrenia
Regular Articles
RC
Subjects
Details
- Language :
- English
- ISSN :
- 26327899
- Database :
- OpenAIRE
- Journal :
- Schizophrenia Bulletin Open
- Accession number :
- edsair.doi.dedup.....e13ee750f119cafe9c8a05e9b7b529f7