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Synthesis and Pharmacological Valorization of Derivatives of 4-Phenyl-1,5-Benzodiazepin-2-One
- Source :
- Advances in Pharmacological Sciences, Advances in Pharmacological Sciences, Vol 2018 (2018)
- Publication Year :
- 2017
-
Abstract
- The objective of our work is to make a pharmacological study of molecules derived from 4-phenyl-1,5-benzodiazepin-2-one carrying long chains so that they have a structure similar to surfactants, with the benzodiazepine as a hydrophilic head and a carbon chain as a hydrophobic tail. First, we studied the acute toxicity of the above mentioned 4-phenyl-1,5-benzodiazepin-2-one derivatives. This study was conducted according to OECD 423 guidelines in female mice and revealed that these compounds are nontoxic. We then assessed the psychotropic effects of our products on the central nervous system (CNS). The results obtained show that 4-phenyl-1,5-benzodiazepin-2-one has no sedative effect at therapeutic doses of 100 and 200 mg/kg. On the other hand, its long-chain derivatives possess them. Moreover, all these products have no cataleptic and hypnotic effects at the doses studied. But at 100 mg/kg, these compounds all have the ability to significantly prolong the hypnotic effect of thiopental sodium.
- Subjects :
- Carbon chain
Hypnotic Effects
Benzodiazepine
Sedative effect
Article Subject
Thiopental Sodium
010405 organic chemistry
medicine.drug_class
Chemistry
lcsh:RM1-950
Pharmacology
010402 general chemistry
01 natural sciences
Acute toxicity
0104 chemical sciences
Hypnotic
lcsh:Therapeutics. Pharmacology
medicine
Molecular Medicine
Pharmacology (medical)
General Pharmacology, Toxicology and Pharmaceutics
Research Article
Subjects
Details
- ISSN :
- 16876334
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- Advances in pharmacological sciences
- Accession number :
- edsair.doi.dedup.....e13ea6bb0571f014c6e38352ce59639b