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Membranous (Class V) Renal Disease in Systemic Lupus Erythematosus May Be More Common Than Previously Reported: Results of a 6-Year Retrospective Analysis
Membranous (Class V) Renal Disease in Systemic Lupus Erythematosus May Be More Common Than Previously Reported: Results of a 6-Year Retrospective Analysis
- Source :
- The American Journal of the Medical Sciences. 339:230-232
- Publication Year :
- 2010
- Publisher :
- Elsevier BV, 2010.
-
Abstract
- Background The actual incidence and prevalence of the various histological classes (based on World Health Organization classification) of lupus nephritis (LN) are not known but seem to vary with sex, age, and ethnicity. We have analyzed renal biopsies in patients with systemic lupus erythematosus (SLE) at our center, and hereby report our experience. Methods All renal biopsies performed at the University of Mississippi between January 1999 and December 2004 in patients with SLE were retrospectively analyzed. Results were validated by a detailed review of renal biopsy reports and additional records were reviewed for data specific to LN disease activity. Results There were 92 renal biopsies performed in patients with SLE during a 6-year period. These included 84 African Americans (72 women and 12 men), 5 whites (4 women and 1 man), and 3 unknown race (1 F, 2 M) subjects. The prevalence of LN classes in our cohort was as follows: class I (0%), class II (9.8%), class III (8.7%), class IV (36.9%), class V (40.2%), and class VI (4.3%). Prevalence of class V LN among males was high at 40%. Conclusions In contrast to previous literature, isolated membranous lupus nephritis (MLN) was much more prevalent in this series—40% versus 14%. Also, no sex difference in the prevalence of MLN was seen. This biopsy cohort suggests that MLN/ class V disease may be more common than previously reported especially in African American population.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Lupus nephritis
Glomerulonephritis, Membranous
Nephropathy
Cohort Studies
Young Adult
Internal medicine
medicine
Humans
Lupus Erythematosus, Systemic
Retrospective Studies
Lupus erythematosus
business.industry
Incidence (epidemiology)
Retrospective cohort study
General Medicine
medicine.disease
Lupus Nephritis
Cohort
Female
business
Kidney disease
Cohort study
Subjects
Details
- ISSN :
- 00029629
- Volume :
- 339
- Database :
- OpenAIRE
- Journal :
- The American Journal of the Medical Sciences
- Accession number :
- edsair.doi.dedup.....e137fb17ec1439d799e20648affa9560
- Full Text :
- https://doi.org/10.1097/maj.0b013e3181c9529c