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Efficacy and Safety of Regorafenib Monotherapy among Patients with Previously Treated Metastatic Colorectal Cancer in a Chinese Population: A Real-World Exploratory Study
Efficacy and Safety of Regorafenib Monotherapy among Patients with Previously Treated Metastatic Colorectal Cancer in a Chinese Population: A Real-World Exploratory Study
- Source :
- International Journal of General Medicine
- Publication Year :
- 2021
-
Abstract
- Rui-Tao Wang, Yang Zhao, An-Lei Wang, Yu-Ting Wang, Zhong-Ping Yin, Kai Chen Department of Oncology, Tianjin Fourth Central Hospital, Tianjin, 300060, Peopleâs Republic of ChinaCorrespondence: Kai ChenDepartment of Oncology, Tianjin Fourth Central Hospital, Tianjin, 300060, Peopleâs Republic of ChinaTel +86 22-2624-9182Email chenkai5103@sina.comBackground: Present study was condeucted to investigate the efficacy and safety of regorafenib for patients with previously treated metastatic colorectal cancer (mCRC) in a Chinese population and the prognostic implications of adverse reactions.Methods: This retrospective study a total of 96 consecutive patients with mCRC who had failed standard chemotherapy regimens from June 2017 to December 2020. Patients received regorafenib at an initial dosage of 160 mg or 120 mg. The primary end point was progression-free survival (PFS), and secondary end points objective response rate (ORR), disease-control rate (DCR), overall survival (OS), safety, and associations between prognosis and adverse-reaction status.Results: There were three patients with partial response, 49 with stable disease, and 44 with progressive disease. Consequently, the ORR and DCR of the 96 patients were 3.1% (95% CI 0.6%â 8.9%) and 54.2% (95% CI 43.7â 64.4%), respectively. Prognosis results showed that median PFS of the 96 patients was 2.5 (95% CI 1.98â 3.02) months and median OS 9.8 (95% CI 7.02â 12.59) months. Additionally, the most frequent adverse reactions during regorafenib treatment were handâfoot syndrome (HFS; 52.1%), hypertension (38.5%), and fatigue (33.3%). Interestingly, the relevance of prognosis to adverse-reaction status exhibited that median PFS of patients with HFS and patients without HFS was 3.3 months and 2.0 months, respectively (P=0.013). Similarly, median PFS of patients with hypertension and without hypertension was 3.6 months and 2.2 months, respectively (P=0.023).Conclusion: Potential clinical benefit of regorafenib monotherapy was observed for patients with mCRC who had failed standard chemotherapy regimens. Hypertension and HFS induced by regorafenib therapy could be used as valuable biomarkers to predict the prognosis of regorafenib.Keywords: colorectal cancer, regorafenib, efficacy, safety, biomarker
- Subjects :
- safety
medicine.medical_specialty
Colorectal cancer
medicine.medical_treatment
efficacy
International Journal of General Medicine
colorectal cancer
Gastroenterology
chemistry.chemical_compound
Stable Disease
Internal medicine
Regorafenib
Clinical endpoint
Medicine
Original Research
Chemotherapy
business.industry
Retrospective cohort study
General Medicine
medicine.disease
chemistry
Biomarker (medicine)
biomarker
regorafenib
business
Progressive disease
Subjects
Details
- ISSN :
- 11787074
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- International journal of general medicine
- Accession number :
- edsair.doi.dedup.....e134fd8b4f4de995ef2d21889ab70cac