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Combined dynamic DCE-MRI and diffusion-weighted imaging to evaluate the effect of neoadjuvant chemotherapy in cervical cancer
- Source :
- Tumori. 106(2)
- Publication Year :
- 2019
-
Abstract
- Purpose: To prospectively investigate changes in quantitative parameters of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and the apparent diffusion coefficient (ADC) of diffusion-weighted imaging (DWI) in patients with cervical cancer before and after neoadjuvant chemotherapy (NACT). Methods: Thirty-eight patients with cervical cancer underwent DCE-MRI and DWI 1 week before and 4 weeks after NACT. The patients were classified into 2 groups: significant reaction (sCR) group and the non-sCR group. DCE-MRI parameters and ADC values were measured and compared between the 2 groups. Results: Before NACT, the mean Ktrans value was higher, but the mean Ve was lower, in the sCR group compared with the non-sCR group; these differences were statistically significant ( ptrans value and the delta (i.e., changed) value of Ktrans were significantly lower in the sCR group compared with the non-sCR group ( ptrans, DKtrans, and pre-mean Ktrans combined with post-mean ADC values were 0.801, 0.955, and 0.878, respectively ( ptrans (0.7020 min−1) and DKtrans (0.0437 min−1). Conclusions: Quantitative parameters (pre-mean Ktrans, DKtrans, and pre-mean Ktrans) combined with post-mean ADC could predict treatment efficacy more precisely. However, quantitative DCE-MRI combined with DWI could not significantly improve prognostic efficacy.
- Subjects :
- Adult
Cancer Research
medicine.medical_treatment
Contrast Media
Uterine Cervical Neoplasms
Disease-Free Survival
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
medicine
Effective diffusion coefficient
Humans
Cervical cancer
Chemotherapy
medicine.diagnostic_test
business.industry
Magnetic resonance imaging
General Medicine
Middle Aged
medicine.disease
Prognosis
Neoadjuvant Therapy
Diffusion Magnetic Resonance Imaging
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Female
Nuclear medicine
business
Diffusion MRI
Subjects
Details
- ISSN :
- 20382529
- Volume :
- 106
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Tumori
- Accession number :
- edsair.doi.dedup.....e12936c4ac188d18d5485bad3d15f4dd