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Cancer cell detector based on a slab waveguide of anisotropic, lossy, and dispersive left-handed material
- Source :
- Applied Optics. 60:8360
- Publication Year :
- 2021
- Publisher :
- Optica Publishing Group, 2021.
-
Abstract
- "Cancer is a disease that takes place when human cells grow uncontrollably. When detected and cured early, it can be non-life-threatening. It becomes life-threatening in case of late discovery where it affects the ability of an organ to function. In this work, a symmetric slab waveguide sensor is analyzed for the detection of cancer cells. The covering layers are assumed anisotropic lossy dispersive left-handed materials. Different from other sensors in which the analyte is located in the cladding region where the evanescent field exists, the cancerous cell is placed in the guiding film region that supports the oscillating field. Hence, the proposed sensor avoids the acute weakness of conven- tional optical waveguide sensors. Due to the high localization of the electromagnetic wave in the analyte region, the proposed sensor shows unusual sensitivity enhancement. The results revealed that the sensitivities obtained are 110%, 325%, and 450% for the first, second, and third modes, respectively. The enhancement of the sensitivity of the third mode relative to the conventional waveguide sensors is nearly a factor of 18." "Cancer is a disease that takes place when human cells grow uncontrollably. When detected and cured early, it can be non-life-threatening. It becomes life-threatening in case of late discovery where it affects the ability of an organ to function. In this work, a symmetric slab waveguide sensor is analyzed for the detection of cancer cells. The covering layers are assumed anisotropic lossy dispersive left-handed materials. Different from other sensors in which the analyte is located in the cladding region where the evanescent field exists, the cancerous cell is placed in the guiding film region that supports the oscillating field. Hence, the proposed sensor avoids the acute weakness of conven- tional optical waveguide sensors. Due to the high localization of the electromagnetic wave in the analyte region, the proposed sensor shows unusual sensitivity enhancement. The results revealed that the sensitivities obtained are 110%, 325%, and 450% for the first, second, and third modes, respectively. The enhancement of the sensitivity of the third mode relative to the conventional waveguide sensors is nearly a factor of 18."
- Subjects :
- Analyte
Materials science
Field (physics)
Biosensing Techniques
waveguide
PC12 Cells
Electromagnetic radiation
Waveguide (optics)
Jurkat Cells
Electromagnetic Fields
Optics
sensor
Neoplasms
Animals
Humans
Electrical and Electronic Engineering
Anisotropy
Engineering (miscellaneous)
Cell Proliferation
Cancer
business.industry
Electromagnetic Radiation
Detector
Cladding (fiber optics)
Atomic and Molecular Physics, and Optics
Rats
Refractometry
MCF-7 Cells
Slab
business
left-handed material
HeLa Cells
Subjects
Details
- ISSN :
- 21553165 and 1559128X
- Volume :
- 60
- Database :
- OpenAIRE
- Journal :
- Applied Optics
- Accession number :
- edsair.doi.dedup.....e11d389499e0fa7cffcae8ece2d008a3
- Full Text :
- https://doi.org/10.1364/ao.437738