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N-Halamine Biocidal Materials with Superior Antimicrobial Efficacies for Wound Dressings
- Source :
- Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, Molecules; Volume 22; Issue 10; Pages: 1582, Molecules, Vol 22, Iss 10, p 1582 (2017)
- Publication Year :
- 2017
- Publisher :
- MDPI AG, 2017.
-
Abstract
- This work demonstrated the successful application of N-halamine technology for wound dressings rendered antimicrobial by facile and inexpensive processes. Four N-halamine compounds, which possess different functional groups and chemistry, were synthesized. The N-halamine compounds, which contained oxidative chlorine, the source of antimicrobial activity, were impregnated into or coated onto standard non-antimicrobial wound dressings. N-halamine-employed wound dressings inactivated about 6 to 7 logs of Staphylococcus aureus and Pseudomonas aeruginosa bacteria in brief periods of contact time. Moreover, the N-halamine-modified wound dressings showed superior antimicrobial efficacies when compared to commercially available silver wound dressings. Zone of inhibition tests revealed that there was no significant leaching of the oxidative chlorine from the materials, and inactivation of bacteria occurred by direct contact. Shelf life stability tests showed that the dressings were stable to loss of oxidative chlorine when they were stored for 6 months in dark environmental conditions. They also remained stable under florescent lighting for up to 2 months of storage. They could be stored in opaque packaging to improve their shelf life stabilities. In vitro skin irritation testing was performed using a three-dimensional human reconstructed tissue model (EpiDermâ„¢). No potential skin irritation was observed. In vitro cytocompatibility was also evaluated. These results indicate that N-halamine wound dressings potentially can be employed to prevent infections, while at the same time improving the healing process by eliminating undesired bacterial growth.
- Subjects :
- Staphylococcus aureus
Contact time
N-halamine
Pharmaceutical Science
chemistry.chemical_element
02 engineering and technology
Bacterial growth
010402 general chemistry
medicine.disease_cause
Shelf life
01 natural sciences
Article
Analytical Chemistry
Microbiology
lcsh:QD241-441
lcsh:Organic chemistry
Anti-Infective Agents
Drug Discovery
medicine
Chlorine
Humans
Agar diffusion test
Physical and Theoretical Chemistry
antibacterial materials
Wound Healing
integumentary system
Pseudomonas aeruginosa
Organic Chemistry
021001 nanoscience & nanotechnology
Antimicrobial
Bandages
Anti-Bacterial Agents
0104 chemical sciences
antimicrobial efficacies
medical wound dressings
chemistry
Chemistry (miscellaneous)
Molecular Medicine
0210 nano-technology
Subjects
Details
- ISSN :
- 14203049
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Molecules
- Accession number :
- edsair.doi.dedup.....e10db2f2bc58de56e5410c74bd3981e7