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High-throughput preparation of radioprotective polymers via Hantzsch’s reaction for in vivo X-ray damage determination
- Source :
- Nature Communications, Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- Radioprotectors for acute injuries caused by large doses of ionizing radiation are vital to national security, public health and future development of humankind. Here, we develop a strategy to explore safe and efficient radioprotectors by combining Hantzsch’s reaction, high-throughput methods and polymer chemistry. A water-soluble polymer with low-cytotoxicity and an excellent anti-radiation capability has been achieved. In in vivo experiments, this polymer is even better than amifostine, which is the only approved radioprotector for clinical applications, in effectively protecting zebrafish embryos from fatally large doses of ionizing radiation (80 Gy X-ray). A mechanistic study also reveals that the radioprotective ability of this polymer originates from its ability to efficiently prevent DNA damage due to high doses of radiation. This is an initial attempt to explore polymer radioprotectors via a multi-component reaction. It allows exploiting functional polymers and provides the underlying insights to guide the design of radioprotective polymers.<br />Nuclear technology has created a significant interest in developing radio-protectants. Here, the authors combine Hantzsch’s reaction with high-throughput techniques for the development of a polymer radio-protectant and demonstrate protection of cells and zebrafish embryos against ionizing radiation.
- Subjects :
- animal structures
Embryo, Nonmammalian
DNA damage
Cell Survival
Polymers
Science
General Physics and Astronomy
Radiation-Protective Agents
Chemistry Techniques, Synthetic
010402 general chemistry
01 natural sciences
General Biochemistry, Genetics and Molecular Biology
Article
Ionizing radiation
Cell Line
Mice
Amifostine
In vivo
High doses
Animals
Zebrafish
chemistry.chemical_classification
Multidisciplinary
Molecular Structure
010405 organic chemistry
X-Rays
X-ray
General Chemistry
Polymer
Fibroblasts
0104 chemical sciences
chemistry
Models, Chemical
embryonic structures
Biophysics
Zebrafish embryo
Polymer synthesis
Comet Assay
Functional polymers
Biomedical materials
DNA Damage
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....e10605ca83fda280ff3a7aa389974f70