Dimethyl fumarate protects the aged brain following chronic cerebral hypoperfusion-related ischemia in rats in Nrf2-dependent manner

Authors :: Mina Ranjbaran
Fardin Sehati
Seyyedeh-Mahla Shavakandi
Ghorbangol Ashabi
Fatemeh Nabavizadeh
Reyhaneh Vali
Source :: Nutritional Neuroscience. 25:2100-2110
Publication Year :: 2021
Publisher :: Informa UK Limited, 2021.
Abstract: It has been stated that chronic cerebral hypoperfusion (CCH) markedly prompts neuronal damage and affects cognition. Dimethyl fumarate (DMF), a nuclear erythroid 2-related factor 2 (Nrf2) activator, represents a class of molecules exhibiting neuroprotection. We explored the effect of DMF on CCH using a model of permanent left common carotid occlusion. The left common carotid artery was occluded and then DMF (100mg.kg

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