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The role of glucose in physiological and pathological heart formation
- Source :
- Dev Biol
- Publication Year :
- 2021
- Publisher :
- eScholarship, University of California, 2021.
-
Abstract
- Cells display distinct metabolic characteristics depending on its differentiation stage. The fuel type of the cells serves not only as a source of energy but also as a driver of differentiation. Glucose, the primary nutrient to the cells, is a critical regulator of rapidly growing embryos. This metabolic change is a consequence as well as a cause of changes in genetic program. Disturbance of fetal glucose metabolism such as in diabetic pregnancy is associated with congenital heart disease. In utero hyperglycemia impacts the left-right axis establishment, migration of cardiac neural crest cells, conotruncal formation and mesenchymal formation of the cardiac cushion during early embryogenesis and causes cardiac hypertrophy in late fetal stages. In this review, we focus on the role of glucose in cardiogenesis and the molecular mechanisms underlying heart diseases associated with hyperglycemia.
- Subjects :
- Heart disease
Organogenesis
Regulator
Cardiovascular
Medical and Health Sciences
Congenital
0302 clinical medicine
Fetal Stage
Pregnancy
2.1 Biological and endogenous factors
Aetiology
Heart formation
Heart Defects
Pediatric
0303 health sciences
Cardiac neural crest cells
Diabetes
Heart
Cell Differentiation
Biological Sciences
medicine.anatomical_structure
Heart Disease
Neural Crest
Prenatal Exposure Delayed Effects
Female
Heart Defects, Congenital
medicine.medical_specialty
1.1 Normal biological development and functioning
Carbohydrate metabolism
Biology
Article
03 medical and health sciences
Underpinning research
Internal medicine
medicine
Animals
Humans
Molecular Biology
Metabolic and endocrine
030304 developmental biology
Nutrition
Fetus
Mesenchymal stem cell
Cell Biology
Perinatal Period - Conditions Originating in Perinatal Period
medicine.disease
Endocrinology
Glucose
Hyperglycemia
030217 neurology & neurosurgery
Developmental Biology
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Dev Biol
- Accession number :
- edsair.doi.dedup.....e0fee9ba7af4f8e435609943e359acce